Altered amino acid profile in patients with SARS-CoV-2 infection

Low plasma arginine bioavailability has been implicated in endothelial dysfunction and immune dysregulation. The role of arginine in COVID-19 is unknown, but could contribute to cellular damage if low. Our objective was to determine arginine bioavailability in adults and children with COVID-19 vs. h...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2021-06, Vol.118 (25), p.1-3
Main Authors: Rees, Chris A., Rostad, Christina A., Mantus, Grace, Anderson, Evan J., Chahroudi, Ann, Jaggi, Preeti, Wrammert, Jens, Ochoa, Juan B., Ochoa, Augusto, Basu, Rajit K., Heilman, Stacy, Harris, Frank, Lapp, Stacey A., Hussaini, Laila, Vos, Miriam B., Brown, Lou Ann, Morris, Claudia R.
Format: Article
Language:English
Subjects:
Adolescents
Adult
Adults
Amino acids
Amino Acids - blood
Arginase
Arginine
Asymptomatic
Bioavailability
Biological Sciences
Biomarkers
BRIEF REPORTS
Children
Citrulline
Coronaviruses
COVID-19
COVID-19 - blood
COVID-19 - therapy
Female
Hospitalization
Humans
Inflammation
Male
Middle Aged
Multisystem inflammatory syndrome in children
Observational studies
Ornithine
Patients
Pediatrics
Respiratory diseases
Retrospective Studies
SARS-CoV-2 - metabolism
Severe acute respiratory syndrome coronavirus 2
Viral diseases
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Summary:Low plasma arginine bioavailability has been implicated in endothelial dysfunction and immune dysregulation. The role of arginine in COVID-19 is unknown, but could contribute to cellular damage if low. Our objective was to determine arginine bioavailability in adults and children with COVID-19 vs. healthy controls. We hypothesized that arginine bioavailability would be low in patients with COVID-19 and multisystem inflammatory syndrome in children (MIS-C). We conducted a prospective observational study of three patient cohorts; arginine bioavailability was determined in asymptomatic healthy controls, adults hospitalized with COVID-19, and hospitalized children/adolescents
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.2101708118