Metastasis pattern and prognosis in men with esophageal cancer patients: A SEER-based study

• Published in: Medicine (Baltimore) 2021-06, Vol.100 (25), p.e26496-e26496
• Main Authors: Zhang, Shengqiang, Guo, Jida, Zhang, Hongyan, Li, Huawei, Hassan, Mohamed Osman Omar, Zhang, Linyou
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Bone Neoplasms - epidemiology; Bone Neoplasms - secondary; Bone Neoplasms - therapy; Brain Neoplasms - epidemiology; Brain Neoplasms - secondary; Brain Neoplasms - therapy; Chemoradiotherapy - statistics & numerical data; Esophageal Neoplasms - mortality; Esophageal Neoplasms - pathology; Esophageal Neoplasms - secondary; Esophageal Neoplasms - therapy; Esophagectomy - statistics & numerical data; Esophagus; Female; Humans; Kaplan-Meier Estimate; Liver Neoplasms - epidemiology; Liver Neoplasms - secondary; Liver Neoplasms - therapy; Lung Neoplasms - epidemiology; Lung Neoplasms - secondary; Lung Neoplasms - therapy; Male; Marital Status - statistics & numerical data; Middle Aged; Observational Study; Prognosis; Retrospective Studies; Risk Factors; SEER Program - statistics & numerical data; Sex Factors; Young Adult
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000026496

Esophageal cancer (EC) is relatively common; at the time of diagnosis, 50% of cases present with distant metastases, and most patients are men. This study aimed to examine and compare the clinicopathological characteristics and metastatic patterns of male EC (MEC) and female EC (FEC). In addition, risk factors associated with MEC prognosis were evaluated.The present study population was extracted from the Surveillance Epidemiology and End Results database. MEC characteristics and factors associated with prognosis were evaluated using descriptive analysis, the Kaplan-Meier method, and the Cox regression model.A total of 12,558 MEC cases were included; among them, 3454 cases had distant organ metastases. Overall, 27.5% of the entire cohort were patients with distant organ metastases. Compared with patients with non-metastatic MEC, patients with metastatic MEC were more likely to be aged ≤60 years, of Black and White race, have a primary lesion in the overlapping esophagus segments, and have a diagnosis of adenocarcinoma of poorly differentiated and undifferentiated grade that was treated with radiotherapy and chemotherapy rather than surgery; moreover, they were also more likely to be married and insured. In addition, patients with MEC were more likely to be aged ≤60 years, White race, and diagnosed with a primary lesion in the lower third of the esophagus and overlapping esophagus segments, and treated without chemotherapy, compared with those with FEC. Patients in the former group were also more likely than those in the latter group to be unmarried and have bone metastasis only and lung metastasis only. Liver, lung, and bone metastases separately, and simultaneous liver and lung metastases were associated with poor survival in MEC patients.Metastatic MEC is associated with clinicopathological characteristics and metastatic patterns different from those associated with non-metastatic MEC and metastatic FEC. Metastatic MEC and FEC patients may have similar prognoses. Distant organ metastasis may be associated with poor prognosis in patients with MEC and FEC.