Transpathology: molecular imaging-based pathology

Pathology is the medical specialty concerned with the study of the disease nature and causes, playing a key role in bridging basic researches and clinical medicine. In the course of development, pathology has significantly expanded our understanding of disease, and exerted enormous impact on the man...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2021-07, Vol.48 (8), p.2338-2350
Main Authors: Tian, Mei, He, Xuexin, Jin, Chentao, He, Xiao, Wu, Shuang, Zhou, Rui, Zhang, Xiaohui, Zhang, Kai, Gu, Weizhong, Wang, Jing, Zhang, Hong
Format: Article
Language:English
Subjects:
Biological activity
Biological Phenomena
Cardiology
Clinical medicine
Editorial
Evaluation
Humans
Imaging
Information processing
Invasiveness
Medical imaging
Medicine
Medicine & Public Health
Molecular Imaging
Nuclear Medicine
Oncology
Orthopedics
Pathology
Precision Medicine
Radiology
Review
Review Article
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Summary:Pathology is the medical specialty concerned with the study of the disease nature and causes, playing a key role in bridging basic researches and clinical medicine. In the course of development, pathology has significantly expanded our understanding of disease, and exerted enormous impact on the management of patients. However, challenges facing pathology, the inherent invasiveness of pathological practice and the persistent concerns on the sample representativeness, constitute its limitations. Molecular imaging is a noninvasive technique to visualize, characterize, and measure biological processes at the molecular level in living subjects. With the continuous development of equipment and probes, molecular imaging has enabled an increasingly precise evaluation of pathophysiological changes. A new pathophysiology visualization system based on molecular imaging is forming and shows the great potential to reform the pathological practice. Several improvements in “trans-,” including trans-scale, transparency, and translation, would be driven by this new kind of pathological practice. Pathological changes could be evaluated in a trans-scale imaging mode; tissues could be transparentized to better present the underlying pathophysiological information; and the translational processes of basic research to the clinical practice would be better facilitated. Thus, transpathology would greatly facilitate in deciphering the pathophysiological events in a multiscale perspective, and supporting the precision medicine in the future.
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-021-05234-1