Evaluation of the relationship between KIM‐1 and suPAR levels and clinical severity in COVID‐19 patients: A different perspective on suPAR

Coronavirus disease 2019 (COVID‐19) is one of the most pressing health problems of this century, but our knowledge of the disease is still limited. In this study, we aimed to examine serum‐soluble urokinase plasminogen activator receptor (suPAR) and kidney injury molecule 1 (KIM‐1) levels based on t...

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Bibliographic Details
Published in:Journal of Medical Virology 2021-09, Vol.93 (9), p.5568-5573
Main Authors: Kerget, Buğra, Kerget, Ferhan, Aksakal, Alperen, Aşkın, Seda, Uçar, Elif Yılmazel, Sağlam, Leyla
Format: Article
Language:English
Subjects:
Coronaviruses
COVID-19
Dimers
Endocytosis
Enzyme-linked immunosorbent assay
Ferritin
Fibrinogen
Fibrinolysis
Health problems
KIM‐1
Lactose
Leukocytes (neutrophilic)
Lymphocytes
Medical personnel
Patients
Prothrombin
Respiratory diseases
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
suPAR
Therapeutic targets
U-Plasminogen activator
Urokinase
Viral diseases
Virology
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Summary:Coronavirus disease 2019 (COVID‐19) is one of the most pressing health problems of this century, but our knowledge of the disease is still limited. In this study, we aimed to examine serum‐soluble urokinase plasminogen activator receptor (suPAR) and kidney injury molecule 1 (KIM‐1) levels based on the clinical course of COVID‐19. Our study included 102 patients over the age of 18 who were diagnosed as having COVID‐19 between September 2020 and December 2020 and a control group of 50 health workers over the age of 18 whose severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) PCR results were negative. KIM‐1 was measured by ELISA and suPAR by suPARnostic™ assay. Analysis of previously identified variables of prognostic significance in COVID‐19 revealed high neutrophil to lymphocyte ratio, lactose dehydrogenase, prothrombin time, C‐reactive protein, PaO2/FiO2, D‐dimer, ferritin, and fibrinogen levels in patients with severe disease (p 
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.27099