Loading…

3D 31P MR spectroscopic imaging of the human brain at 3 T with a 31P receive array: An assessment of 1H decoupling, T1 relaxation times, 1H‐31P nuclear Overhauser effects and NAD

31P MR spectroscopic imaging (MRSI) is a versatile technique to study phospholipid precursors and energy metabolism in the healthy and diseased human brain. However, mainly due to its low sensitivity, 31P MRSI is currently limited to research purposes. To obtain 3D 31P MRSI spectra with improved sig...

Full description

Saved in:
Bibliographic Details
Published in:NMR in biomedicine 2021-05, Vol.34 (5), p.n/a
Main Authors: Peeters, Tom H., Uden, Mark J., Rijpma, Anne, Scheenen, Tom W.J., Heerschap, Arend
Format: Article
Language:English
Subjects:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page n/a
container_issue 5
container_start_page
container_title NMR in biomedicine
container_volume 34
creator Peeters, Tom H.
Uden, Mark J.
Rijpma, Anne
Scheenen, Tom W.J.
Heerschap, Arend
description 31P MR spectroscopic imaging (MRSI) is a versatile technique to study phospholipid precursors and energy metabolism in the healthy and diseased human brain. However, mainly due to its low sensitivity, 31P MRSI is currently limited to research purposes. To obtain 3D 31P MRSI spectra with improved signal‐to‐noise ratio on clinical 3 T MR systems, we used a coil combination consisting of a dual‐tuned birdcage transmit coil and a 31P eight‐channel phased‐array receive insert. To further increase resolution and sensitivity we applied WALTZ4 1H decoupling and continuous wave nuclear Overhauser effect (NOE) enhancement and acquired high‐quality MRSI spectra with nominal voxel volumes of ~ 17.6 cm3 (effective voxel volume ~ 51 cm3) in a clinically relevant measurement time of ~ 13 minutes, without exceeding SAR limits. Steady‐state NOE enhancements ranged from 15 ± 9% (γ‐ATP) and 33 ± 3% (phosphocreatine) to 48 ± 11% (phosphoethanolamine). Because of these improvements, we resolved and detected all 31P signals of metabolites that have also been reported for ultrahigh field strengths, including resonances for NAD+, NADH and extracellular inorganic phosphate. T1 times of extracellular inorganic phosphate were longer than for intracellular inorganic phosphate (3.8 ± 1.4s vs 1.8 ± 0.65 seconds). A comparison of measured T1 relaxation times and NOE enhancements at 3 T with published values between 1.5 and 9.4 T indicates that T1 relaxation of 31P metabolite spins in the human brain is dominated by dipolar relaxation for this field strength range. Even although intrinsic sensitivity is higher at ultrahigh fields, we demonstrate that at a clinical field strength of 3 T, similar 31P MRSI information content can be obtained using a sophisticated coil design combined with 1H decoupling and NOE enhancement. We performed 3D 31P MRSI of the human brain at 3 T employing a 1H/31P dual‐tuned birdcage transmit coil and a 31P 8‐channel phased‐array receive insert to acquire high‐quality 31P MR spectra with and without 1H‐decoupling and/or 1H‐31P NOE. The well‐resolved spectra allowed to analyze two peaks for inorganic phosphate and the NAD+/NADH redox ratio. Localized T1 relaxation times and NOE enhancements of 31P spins were measured and compared with those acquired at other field strengths, indicating little effect of chemical shift anisotropy relaxation.
doi_str_mv 10.1002/nbm.4169
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8244063</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2514208820</sourcerecordid><originalsourceid>FETCH-LOGICAL-p1559-dff65c0f060aaed6d9aacf56d71c2979b2e53d200cb47f4f953543086f1c42a83</originalsourceid><addsrcrecordid>eNpVkc1u1DAUhS0EokNB4hGuxLYp_s3ELJCGFihSfxAa1pbj2BNXiRPsZMrseAQehifiSXBohcTqLu45n869B6GXBJ8SjOnrUPennJTyEVoRLGVBuKSP0QpLQQvGK3yEnqV0izGuOKNP0REjglSYlSv0i50DI5_h6guk0ZopDskMozfge73zYQeDg6m10M69DlBH7QPoCRhs4c5PLei_7miN9XsLOkZ9eAObrEnJptTbMC0EcgGNNcM8dhl5AluSHZ3-ric_BJh8b9NJ1vz-8XOBhdl0Vke42dvY6jnZCNa5nC2BDg1cb86foydOd8m-eJjH6OuH99uzi-Ly5uOns81lMRIhZNE4VwqDHS6x1rYpG6m1caJs1sRQuZY1tYI1FGNT87XjTgomOMNV6YjhVFfsGL29545z3dvG5Gui7tQY83PiQQ3aq_83wbdqN-xVRTnHJcuAVw-AOHybbZrU7TDHkDMrKginuKoozqriXnXnO3v4hydYLeWqXK5aylXX766Wyf4AVB2YEg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2514208820</pqid></control><display><type>article</type><title>3D 31P MR spectroscopic imaging of the human brain at 3 T with a 31P receive array: An assessment of 1H decoupling, T1 relaxation times, 1H‐31P nuclear Overhauser effects and NAD</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Peeters, Tom H. ; Uden, Mark J. ; Rijpma, Anne ; Scheenen, Tom W.J. ; Heerschap, Arend</creator><creatorcontrib>Peeters, Tom H. ; Uden, Mark J. ; Rijpma, Anne ; Scheenen, Tom W.J. ; Heerschap, Arend</creatorcontrib><description>31P MR spectroscopic imaging (MRSI) is a versatile technique to study phospholipid precursors and energy metabolism in the healthy and diseased human brain. However, mainly due to its low sensitivity, 31P MRSI is currently limited to research purposes. To obtain 3D 31P MRSI spectra with improved signal‐to‐noise ratio on clinical 3 T MR systems, we used a coil combination consisting of a dual‐tuned birdcage transmit coil and a 31P eight‐channel phased‐array receive insert. To further increase resolution and sensitivity we applied WALTZ4 1H decoupling and continuous wave nuclear Overhauser effect (NOE) enhancement and acquired high‐quality MRSI spectra with nominal voxel volumes of ~ 17.6 cm3 (effective voxel volume ~ 51 cm3) in a clinically relevant measurement time of ~ 13 minutes, without exceeding SAR limits. Steady‐state NOE enhancements ranged from 15 ± 9% (γ‐ATP) and 33 ± 3% (phosphocreatine) to 48 ± 11% (phosphoethanolamine). Because of these improvements, we resolved and detected all 31P signals of metabolites that have also been reported for ultrahigh field strengths, including resonances for NAD+, NADH and extracellular inorganic phosphate. T1 times of extracellular inorganic phosphate were longer than for intracellular inorganic phosphate (3.8 ± 1.4s vs 1.8 ± 0.65 seconds). A comparison of measured T1 relaxation times and NOE enhancements at 3 T with published values between 1.5 and 9.4 T indicates that T1 relaxation of 31P metabolite spins in the human brain is dominated by dipolar relaxation for this field strength range. Even although intrinsic sensitivity is higher at ultrahigh fields, we demonstrate that at a clinical field strength of 3 T, similar 31P MRSI information content can be obtained using a sophisticated coil design combined with 1H decoupling and NOE enhancement. We performed 3D 31P MRSI of the human brain at 3 T employing a 1H/31P dual‐tuned birdcage transmit coil and a 31P 8‐channel phased‐array receive insert to acquire high‐quality 31P MR spectra with and without 1H‐decoupling and/or 1H‐31P NOE. The well‐resolved spectra allowed to analyze two peaks for inorganic phosphate and the NAD+/NADH redox ratio. Localized T1 relaxation times and NOE enhancements of 31P spins were measured and compared with those acquired at other field strengths, indicating little effect of chemical shift anisotropy relaxation.</description><identifier>ISSN: 0952-3480</identifier><identifier>EISSN: 1099-1492</identifier><identifier>DOI: 10.1002/nbm.4169</identifier><identifier>PMID: 31518036</identifier><language>eng</language><publisher>Oxford: Wiley Subscription Services, Inc</publisher><subject>1H decoupling ; 31P MR spectroscopic imaging ; 3 T ; Arrays ; Biological products ; Brain ; Continuous radiation ; Decoupling ; Energy metabolism ; Field strength ; Magnetic resonance imaging ; Metabolites ; NAD ; NADH ; Neuroimaging ; Nicotinamide adenine dinucleotide ; nuclear Overhauser effect ; Overhauser effect ; Phosphocreatine ; Phospholipids ; Sensitivity ; Special Issue ; Special Issue s</subject><ispartof>NMR in biomedicine, 2021-05, Vol.34 (5), p.n/a</ispartof><rights>2019 The Authors. published by John Wiley &amp; Sons Ltd</rights><rights>2019. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-6244-6938</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids></links><search><creatorcontrib>Peeters, Tom H.</creatorcontrib><creatorcontrib>Uden, Mark J.</creatorcontrib><creatorcontrib>Rijpma, Anne</creatorcontrib><creatorcontrib>Scheenen, Tom W.J.</creatorcontrib><creatorcontrib>Heerschap, Arend</creatorcontrib><title>3D 31P MR spectroscopic imaging of the human brain at 3 T with a 31P receive array: An assessment of 1H decoupling, T1 relaxation times, 1H‐31P nuclear Overhauser effects and NAD</title><title>NMR in biomedicine</title><description>31P MR spectroscopic imaging (MRSI) is a versatile technique to study phospholipid precursors and energy metabolism in the healthy and diseased human brain. However, mainly due to its low sensitivity, 31P MRSI is currently limited to research purposes. To obtain 3D 31P MRSI spectra with improved signal‐to‐noise ratio on clinical 3 T MR systems, we used a coil combination consisting of a dual‐tuned birdcage transmit coil and a 31P eight‐channel phased‐array receive insert. To further increase resolution and sensitivity we applied WALTZ4 1H decoupling and continuous wave nuclear Overhauser effect (NOE) enhancement and acquired high‐quality MRSI spectra with nominal voxel volumes of ~ 17.6 cm3 (effective voxel volume ~ 51 cm3) in a clinically relevant measurement time of ~ 13 minutes, without exceeding SAR limits. Steady‐state NOE enhancements ranged from 15 ± 9% (γ‐ATP) and 33 ± 3% (phosphocreatine) to 48 ± 11% (phosphoethanolamine). Because of these improvements, we resolved and detected all 31P signals of metabolites that have also been reported for ultrahigh field strengths, including resonances for NAD+, NADH and extracellular inorganic phosphate. T1 times of extracellular inorganic phosphate were longer than for intracellular inorganic phosphate (3.8 ± 1.4s vs 1.8 ± 0.65 seconds). A comparison of measured T1 relaxation times and NOE enhancements at 3 T with published values between 1.5 and 9.4 T indicates that T1 relaxation of 31P metabolite spins in the human brain is dominated by dipolar relaxation for this field strength range. Even although intrinsic sensitivity is higher at ultrahigh fields, we demonstrate that at a clinical field strength of 3 T, similar 31P MRSI information content can be obtained using a sophisticated coil design combined with 1H decoupling and NOE enhancement. We performed 3D 31P MRSI of the human brain at 3 T employing a 1H/31P dual‐tuned birdcage transmit coil and a 31P 8‐channel phased‐array receive insert to acquire high‐quality 31P MR spectra with and without 1H‐decoupling and/or 1H‐31P NOE. The well‐resolved spectra allowed to analyze two peaks for inorganic phosphate and the NAD+/NADH redox ratio. Localized T1 relaxation times and NOE enhancements of 31P spins were measured and compared with those acquired at other field strengths, indicating little effect of chemical shift anisotropy relaxation.</description><subject>1H decoupling</subject><subject>31P MR spectroscopic imaging</subject><subject>3 T</subject><subject>Arrays</subject><subject>Biological products</subject><subject>Brain</subject><subject>Continuous radiation</subject><subject>Decoupling</subject><subject>Energy metabolism</subject><subject>Field strength</subject><subject>Magnetic resonance imaging</subject><subject>Metabolites</subject><subject>NAD</subject><subject>NADH</subject><subject>Neuroimaging</subject><subject>Nicotinamide adenine dinucleotide</subject><subject>nuclear Overhauser effect</subject><subject>Overhauser effect</subject><subject>Phosphocreatine</subject><subject>Phospholipids</subject><subject>Sensitivity</subject><subject>Special Issue</subject><subject>Special Issue s</subject><issn>0952-3480</issn><issn>1099-1492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNpVkc1u1DAUhS0EokNB4hGuxLYp_s3ELJCGFihSfxAa1pbj2BNXiRPsZMrseAQehifiSXBohcTqLu45n869B6GXBJ8SjOnrUPennJTyEVoRLGVBuKSP0QpLQQvGK3yEnqV0izGuOKNP0REjglSYlSv0i50DI5_h6guk0ZopDskMozfge73zYQeDg6m10M69DlBH7QPoCRhs4c5PLei_7miN9XsLOkZ9eAObrEnJptTbMC0EcgGNNcM8dhl5AluSHZ3-ric_BJh8b9NJ1vz-8XOBhdl0Vke42dvY6jnZCNa5nC2BDg1cb86foydOd8m-eJjH6OuH99uzi-Ly5uOns81lMRIhZNE4VwqDHS6x1rYpG6m1caJs1sRQuZY1tYI1FGNT87XjTgomOMNV6YjhVFfsGL29545z3dvG5Gui7tQY83PiQQ3aq_83wbdqN-xVRTnHJcuAVw-AOHybbZrU7TDHkDMrKginuKoozqriXnXnO3v4hydYLeWqXK5aylXX766Wyf4AVB2YEg</recordid><startdate>202105</startdate><enddate>202105</enddate><creator>Peeters, Tom H.</creator><creator>Uden, Mark J.</creator><creator>Rijpma, Anne</creator><creator>Scheenen, Tom W.J.</creator><creator>Heerschap, Arend</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6244-6938</orcidid></search><sort><creationdate>202105</creationdate><title>3D 31P MR spectroscopic imaging of the human brain at 3 T with a 31P receive array: An assessment of 1H decoupling, T1 relaxation times, 1H‐31P nuclear Overhauser effects and NAD</title><author>Peeters, Tom H. ; Uden, Mark J. ; Rijpma, Anne ; Scheenen, Tom W.J. ; Heerschap, Arend</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1559-dff65c0f060aaed6d9aacf56d71c2979b2e53d200cb47f4f953543086f1c42a83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>1H decoupling</topic><topic>31P MR spectroscopic imaging</topic><topic>3 T</topic><topic>Arrays</topic><topic>Biological products</topic><topic>Brain</topic><topic>Continuous radiation</topic><topic>Decoupling</topic><topic>Energy metabolism</topic><topic>Field strength</topic><topic>Magnetic resonance imaging</topic><topic>Metabolites</topic><topic>NAD</topic><topic>NADH</topic><topic>Neuroimaging</topic><topic>Nicotinamide adenine dinucleotide</topic><topic>nuclear Overhauser effect</topic><topic>Overhauser effect</topic><topic>Phosphocreatine</topic><topic>Phospholipids</topic><topic>Sensitivity</topic><topic>Special Issue</topic><topic>Special Issue s</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peeters, Tom H.</creatorcontrib><creatorcontrib>Uden, Mark J.</creatorcontrib><creatorcontrib>Rijpma, Anne</creatorcontrib><creatorcontrib>Scheenen, Tom W.J.</creatorcontrib><creatorcontrib>Heerschap, Arend</creatorcontrib><collection>Wiley Open Access</collection><collection>Wiley Free Archive</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>NMR in biomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peeters, Tom H.</au><au>Uden, Mark J.</au><au>Rijpma, Anne</au><au>Scheenen, Tom W.J.</au><au>Heerschap, Arend</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>3D 31P MR spectroscopic imaging of the human brain at 3 T with a 31P receive array: An assessment of 1H decoupling, T1 relaxation times, 1H‐31P nuclear Overhauser effects and NAD</atitle><jtitle>NMR in biomedicine</jtitle><date>2021-05</date><risdate>2021</risdate><volume>34</volume><issue>5</issue><epage>n/a</epage><issn>0952-3480</issn><eissn>1099-1492</eissn><abstract>31P MR spectroscopic imaging (MRSI) is a versatile technique to study phospholipid precursors and energy metabolism in the healthy and diseased human brain. However, mainly due to its low sensitivity, 31P MRSI is currently limited to research purposes. To obtain 3D 31P MRSI spectra with improved signal‐to‐noise ratio on clinical 3 T MR systems, we used a coil combination consisting of a dual‐tuned birdcage transmit coil and a 31P eight‐channel phased‐array receive insert. To further increase resolution and sensitivity we applied WALTZ4 1H decoupling and continuous wave nuclear Overhauser effect (NOE) enhancement and acquired high‐quality MRSI spectra with nominal voxel volumes of ~ 17.6 cm3 (effective voxel volume ~ 51 cm3) in a clinically relevant measurement time of ~ 13 minutes, without exceeding SAR limits. Steady‐state NOE enhancements ranged from 15 ± 9% (γ‐ATP) and 33 ± 3% (phosphocreatine) to 48 ± 11% (phosphoethanolamine). Because of these improvements, we resolved and detected all 31P signals of metabolites that have also been reported for ultrahigh field strengths, including resonances for NAD+, NADH and extracellular inorganic phosphate. T1 times of extracellular inorganic phosphate were longer than for intracellular inorganic phosphate (3.8 ± 1.4s vs 1.8 ± 0.65 seconds). A comparison of measured T1 relaxation times and NOE enhancements at 3 T with published values between 1.5 and 9.4 T indicates that T1 relaxation of 31P metabolite spins in the human brain is dominated by dipolar relaxation for this field strength range. Even although intrinsic sensitivity is higher at ultrahigh fields, we demonstrate that at a clinical field strength of 3 T, similar 31P MRSI information content can be obtained using a sophisticated coil design combined with 1H decoupling and NOE enhancement. We performed 3D 31P MRSI of the human brain at 3 T employing a 1H/31P dual‐tuned birdcage transmit coil and a 31P 8‐channel phased‐array receive insert to acquire high‐quality 31P MR spectra with and without 1H‐decoupling and/or 1H‐31P NOE. The well‐resolved spectra allowed to analyze two peaks for inorganic phosphate and the NAD+/NADH redox ratio. Localized T1 relaxation times and NOE enhancements of 31P spins were measured and compared with those acquired at other field strengths, indicating little effect of chemical shift anisotropy relaxation.</abstract><cop>Oxford</cop><pub>Wiley Subscription Services, Inc</pub><pmid>31518036</pmid><doi>10.1002/nbm.4169</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-6244-6938</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0952-3480
ispartof NMR in biomedicine, 2021-05, Vol.34 (5), p.n/a
issn 0952-3480
1099-1492
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8244063
source Wiley-Blackwell Read & Publish Collection
subjects 1H decoupling
31P MR spectroscopic imaging
3 T
Arrays
Biological products
Brain
Continuous radiation
Decoupling
Energy metabolism
Field strength
Magnetic resonance imaging
Metabolites
NAD
NADH
Neuroimaging
Nicotinamide adenine dinucleotide
nuclear Overhauser effect
Overhauser effect
Phosphocreatine
Phospholipids
Sensitivity
Special Issue
Special Issue s
title 3D 31P MR spectroscopic imaging of the human brain at 3 T with a 31P receive array: An assessment of 1H decoupling, T1 relaxation times, 1H‐31P nuclear Overhauser effects and NAD
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T15%3A40%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=3D%2031P%20MR%20spectroscopic%20imaging%20of%20the%20human%20brain%20at%203%20T%20with%20a%2031P%20receive%20array:%20An%20assessment%20of%201H%20decoupling,%20T1%20relaxation%20times,%201H%E2%80%9031P%20nuclear%20Overhauser%20effects%20and%20NAD&rft.jtitle=NMR%20in%20biomedicine&rft.au=Peeters,%20Tom%20H.&rft.date=2021-05&rft.volume=34&rft.issue=5&rft.epage=n/a&rft.issn=0952-3480&rft.eissn=1099-1492&rft_id=info:doi/10.1002/nbm.4169&rft_dat=%3Cproquest_pubme%3E2514208820%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-p1559-dff65c0f060aaed6d9aacf56d71c2979b2e53d200cb47f4f953543086f1c42a83%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2514208820&rft_id=info:pmid/31518036&rfr_iscdi=true