Longitudinal changes in red blood cell distribution width decades after radiation exposure in atomic‐bomb survivors

Summary Red blood cell distribution width (RDW), which generally increases with age, is a risk marker for morbidity and mortality in various diseases. We investigated the association between elevated RDW and prior radiation exposure by examining longitudinal RDW changes in 4204 atomic‐bomb survivors...

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Bibliographic Details
Published in:British journal of haematology 2021-04, Vol.193 (2), p.406-409
Main Authors: Yoshida, Kengo, Misumi, Munechika, Kusunoki, Yoichiro, Yamada, Michiko
Format: Article
Language:English
Subjects:
Erythrocytes
Haematopoiesis
Hematology
Morbidity
Mortality
RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT
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Summary:Summary Red blood cell distribution width (RDW), which generally increases with age, is a risk marker for morbidity and mortality in various diseases. We investigated the association between elevated RDW and prior radiation exposure by examining longitudinal RDW changes in 4204 atomic‐bomb survivors over 15 years. A positive association was found between RDW and radiation dose, wherein RDW increased by 0·18%/Gy. This radiation‐associated effect increased as the participants aged. Elevated RDW was also associated with higher all‐cause mortality. The biological mechanisms underlying these observed associations merit further investigation.
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.17296