Consumption of High‐Oleic Soybean Oil Improves Lipid and Lipoprotein Profile in Humans Compared to a Palm Oil Blend: A Randomized Controlled Trial

Partially hydrogenated oils (PHO) have been removed from the food supply due to adverse effects on risk for coronary heart disease (CHD). High‐oleic soybean oils (HOSBO) are alternatives that provide functionality for different food applications. The objective of this study was to determine how cons...

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Bibliographic Details
Published in:Lipids 2021-05, Vol.56 (3), p.313-325
Main Authors: Baer, David J., Henderson, Theresa, Gebauer, Sarah K.
Format: Article
Language:English
Subjects:
Apolipoprotein A-I - metabolism
Body composition
Cholesterol, LDL - blood
Coronary heart disease
Cross-Over Studies
Healthy Volunteers
High‐oleic soybean oil
Humans
Hydrogenation
LDL cholesterol
Lipid Peroxides - blood
Middle Aged
Original
Palm oil
Palm Oil - administration & dosage
Palm Oil - chemistry
Palm Oil - pharmacology
Soybean oil
Soybean Oil - administration & dosage
Soybean Oil - chemistry
Soybean Oil - pharmacology
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Summary:Partially hydrogenated oils (PHO) have been removed from the food supply due to adverse effects on risk for coronary heart disease (CHD). High‐oleic soybean oils (HOSBO) are alternatives that provide functionality for different food applications. The objective of this study was to determine how consumption of diets containing HOSBO compared to other alternative oils, with similar functional properties, modifies LDL cholesterol (LDLc) and other risk factors and biomarkers of CHD. A triple‐blind, crossover, randomized controlled trial was conducted in humans (n = 60) with four highly‐controlled diets containing (1) HOSBO, (2) 80:20 blend of HOSBO and fully hydrogenated soybean oil (HOSBO+FHSBO), (3) soybean oil (SBO), and (4) 50:50 blend of palm oil and palm kernel oil (PO + PKO). Before and after 29 days of feeding, lipids/lipoproteins, blood pressure, body composition, and markers of inflammation, oxidation, and hemostasis were measured. LDLc, apolipoprotein B (apoB), NonHDL‐cholesterol (HDLc), ratios of total cholesterol (TC)‐to‐HDLc and LDLc‐to‐HDL cholesterol, and LDL particle number and small LDL particles concentration were lower after HOSBO and HOSBO+FHSBO compared to PO (specific comparisons p 
ISSN:0024-4201
1558-9307
DOI:10.1002/lipd.12298