Molecular Imaging Using Cardiac PET/CT: Opportunities to Harmonize Diagnosis and Therapy

Purpose of Review Current therapeutic strategies to mitigate heart failure progression after myocardial infarction involve support of endogenous repair through molecular targets. The capacity for repair varies greatly between individuals. In this review, we will assess how cardiac PET/CT enables pre...

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Bibliographic Details
Published in:Current cardiology reports 2021-08, Vol.23 (8), p.96, Article 96
Main Author: Thackeray, James T.
Format: Article
Language:English
Subjects:
Cardiology
Heart
Humans
Medicine
Medicine & Public Health
Molecular Imaging
Myocardial Infarction - diagnostic imaging
Myocardial Infarction - therapy
Nuclear Cardiology (V Dilsizian
Nuclear Cardiology (V Dilsizian, Section Editor)
Positron Emission Tomography Computed Tomography
Section Editor
Topical Collection on Nuclear Cardiology
Ventricular Remodeling
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Summary:Purpose of Review Current therapeutic strategies to mitigate heart failure progression after myocardial infarction involve support of endogenous repair through molecular targets. The capacity for repair varies greatly between individuals. In this review, we will assess how cardiac PET/CT enables precise characterization of early pathogenetic processes which govern ventricle remodeling and progression to heart failure. Recent Findings Inflammation in the first days after myocardial infarction predicts subsequent functional decline and can influence therapy decisions. The expansion of anti-inflammatory approaches to improve outcomes after myocardial infarction may benefit from noninvasive characterization using imaging. Novel probes also allow visualization of fibroblast transdifferentiation and activation, as a precursor to ventricle remodeling. Summary The expanding arsenal of molecular imaging agents in parallel with new treatment options provides opportunity to harmonize diagnostic imaging with precision therapy.
ISSN:1523-3782
1534-3170
1534-3170
DOI:10.1007/s11886-021-01526-y