Pathogenic Characterization of a Porcine Circovirus Type 3 Isolate from Heilongjiang, China

The clinical outcome of porcine circovirus 3 (PCV3) infection is still controversial. Herein, a novel PCV3 isolate (PCV3-China/DB-1/2017) with the molecular characterization of 24A and 27K in the Cap protein was used to inoculate three-week-old cesarean-derived, colostrum-deprived piglets. The nine...

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Bibliographic Details
Published in:Disease markers 2021, Vol.2021, p.9434944-8
Main Authors: Wang, Menghang, Yu, Ying, Wu, Jianan, Meng, Fandan, Tang, Yandong, Wang, Shujie, Wang, Yu, Cui, Hongliang, He, Xijun, Tu, Yabin, Wang, Gang, Cai, Xuehui
Format: Article
Language:English
Subjects:
Amino acids
Animals
Antibodies, Viral - metabolism
Asymptomatic Infections
Biomarkers - metabolism
Brain
China
Circoviridae Infections - immunology
Circoviridae Infections - pathology
Circoviridae Infections - veterinary
Circoviridae Infections - virology
Circovirus - genetics
Circovirus - immunology
Circovirus - isolation & purification
Circovirus - pathogenicity
Colostrum
Experiments
Genome, Viral
Genomes
Hogs
IgG antibody
Immunoglobulin G
Inoculation
Kidneys
Lungs
Lymph nodes
Lymphatic system
Organs
Pathogenicity
Pathogens
Phylogenetics
Proteins
Random Allocation
Spleen
Sus scrofa
Swine
Swine Diseases - immunology
Swine Diseases - pathology
Swine Diseases - virology
Tonsil
Viral Load
Viral Proteins - genetics
Viral Proteins - immunology
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Summary:The clinical outcome of porcine circovirus 3 (PCV3) infection is still controversial. Herein, a novel PCV3 isolate (PCV3-China/DB-1/2017) with the molecular characterization of 24A and 27K in the Cap protein was used to inoculate three-week-old cesarean-derived, colostrum-deprived piglets. The nine PCV3 DB-1 inoculated piglets exhibited no obvious clinical symptoms or macroscopic lesions. PCV3 displayed a broad histotropism, including the heart, liver, spleen, lung, kidney, brain, lymph nodes, and tonsil, and the lungs and lymph nodes contained a higher quantity of viral genomes compared to that of the other organs. From 7 days after PCV3 DB-1 inoculation, the piglets showed obvious IgG antibody responses against PCV3 rCap-VLPs. The cumulative results demonstrated that PCV3 trend to low pathogenicity.
ISSN:0278-0240
1875-8630
DOI:10.1155/2021/9434944