Insulin-like Growth Factor 1 and Prolactin Levels in Chimpanzees (Pan troglodytes) Across the Lifespan

Abstract As human and chimpanzee genomes show high homology for IGF1 and PRL, we analyzed the sera of 367 healthy chimpanzees obtained during routine physical examinations in a single colony and measured chimpanzee insulin-like growth factor (IGF)-1 and prolactin (PRL) levels across the lifespan usi...

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Bibliographic Details
Published in:Journal of the Endocrine Society 2021-08, Vol.5 (8), p.bvab063-bvab063
Main Authors: Ben-Shlomo, Anat, McLachlan, Sandra M, Hwe, Jennifer, Aliesky, Holly, Hasselschwert, Dana, Mirocha, James, Melmed, Shlomo
Format: Article
Language:English
Subjects:
Analysis
Chimpanzees
Genomics
Prolactin
Puberty
Somatotropin
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Summary:Abstract As human and chimpanzee genomes show high homology for IGF1 and PRL, we analyzed the sera of 367 healthy chimpanzees obtained during routine physical examinations in a single colony and measured chimpanzee insulin-like growth factor (IGF)-1 and prolactin (PRL) levels across the lifespan using standard human immunoassays. Assuming chimpanzee IGF-1 levels peak during puberty as in humans, we randomly defined puberty as the age at which most IGF-1 levels were equal to or above the 90th percentile for each sex (males, ages ≥7.00 but
ISSN:2472-1972
2472-1972
DOI:10.1210/jendso/bvab063