Correlations between FTO Gene Polymorphisms and TSH Level in Uyghur Chinese Patients with Type 2 Diabetes

Objective. The aim of this study was to investigate the correlation between polymorphisms in the FTO gene and TSH level in Uyghur patients with type 2 diabetes in the Xinjiang region. Material and Methods. This cohort was made up of 498 Uyghur patients with type 2 diabetes who underwent genotype scr...

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Bibliographic Details
Published in:BioMed research international 2021, Vol.2021, p.6646750-7
Main Authors: Wang, Li, Yi, QiZhong, Yao, Hua, He, LiJuan, Fang, BinBin, Xu, WeiFang, Su, YinXia, Liu, JiWen, Ma, Qi
Format: Article
Language:English
Subjects:
Adult
Age
Alleles
Alpha-Ketoglutarate-Dependent Dioxygenase FTO - genetics
Asians
Blood pressure
Body Mass Index
China - epidemiology
China - ethnology
Cholesterol
Cohort Studies
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - genetics
Disease
Female
Fto gene
Gene polymorphism
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Genotypes
Glucose
Glycated Hemoglobin A - genetics
Hospitals
Humans
Life Style
Lipoproteins
Male
Males
Middle Aged
Obesity
Polymorphism, Single Nucleotide
Population
Regression Analysis
Risk analysis
Risk Factors
Standard deviation
Thyroid gland
Thyrotropin - blood
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Summary:Objective. The aim of this study was to investigate the correlation between polymorphisms in the FTO gene and TSH level in Uyghur patients with type 2 diabetes in the Xinjiang region. Material and Methods. This cohort was made up of 498 Uyghur patients with type 2 diabetes who underwent genotype screening for rs8050136 and rs9939609 using the Sequenom MassARRAY system. The distribution frequencies of the genotypes and alleles at rs8050136 and rs993960 were compared between two patient groups, those with TSH
ISSN:2314-6133
2314-6141
DOI:10.1155/2021/6646750