Successful single kidney transplantation from pediatric donors less than or equal to 10 kg to adult recipient: a retrospective cohort study

BACKGROUNDKidneys from very small pediatric donors (≤10 kg) are underutilized. Compared to en bloc kidney transplantation (EBKT), single kidney transplantation (SKT) can maximize donor resources. However, it remains unknown whether it's appropriate to perform SKTs from donors weighing ≤10 kg. M...

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Published in:Translational pediatrics 2021-06, Vol.10 (6), p.1618-1629
Main Authors: Chen, Chuxiao, Su, Xiaojun, Wu, Chenglin, Liu, Longshan, Zhang, Huanxi, Deng, Ronghai, Fu, Qian, Yuan, Xiaopeng, Zheng, Yitao, Qiu, Jiang, Chen, Guodong, Huang, Gang, Deng, Suxiong, Fei, Jiguang, Chen, Lizhong, Li, Jun, Wang, Changxi
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container_end_page 1629
container_issue 6
container_start_page 1618
container_title Translational pediatrics
container_volume 10
creator Chen, Chuxiao
Su, Xiaojun
Wu, Chenglin
Liu, Longshan
Zhang, Huanxi
Deng, Ronghai
Fu, Qian
Yuan, Xiaopeng
Zheng, Yitao
Qiu, Jiang
Chen, Guodong
Huang, Gang
Deng, Suxiong
Fei, Jiguang
Chen, Lizhong
Li, Jun
Wang, Changxi
description BACKGROUNDKidneys from very small pediatric donors (≤10 kg) are underutilized. Compared to en bloc kidney transplantation (EBKT), single kidney transplantation (SKT) can maximize donor resources. However, it remains unknown whether it's appropriate to perform SKTs from donors weighing ≤10 kg. METHODSA total of 35 adult recipients undergoing kidney transplantation from donors weighing ≤10 kg at our center from December 2014 to December 2019 were included and grouped into SKT group (n=20) and EBKT group (n=15). Transplant outcomes were retrospectively analyzed and compared between 2 groups. RESULTSThe 1-year and 3-year death-censored graft survival in SKT group was 95%, it is not significantly higher than that in EBKT group (80%, log-rank test, P=0.38). Significant improvement in estimated glomerular filtration rate (eGFR) was noted in both groups, despite eGFR at 1 year was lower in the SKT group (P
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Compared to en bloc kidney transplantation (EBKT), single kidney transplantation (SKT) can maximize donor resources. However, it remains unknown whether it's appropriate to perform SKTs from donors weighing ≤10 kg. METHODSA total of 35 adult recipients undergoing kidney transplantation from donors weighing ≤10 kg at our center from December 2014 to December 2019 were included and grouped into SKT group (n=20) and EBKT group (n=15). Transplant outcomes were retrospectively analyzed and compared between 2 groups. RESULTSThe 1-year and 3-year death-censored graft survival in SKT group was 95%, it is not significantly higher than that in EBKT group (80%, log-rank test, P=0.38). Significant improvement in estimated glomerular filtration rate (eGFR) was noted in both groups, despite eGFR at 1 year was lower in the SKT group (P&lt;0.01). Proteinuria was common in both groups but subsided gradually during the follow-up time. Complication rates were similar between 2 groups with no vascular thrombosis in the SKT group. CONCLUSIONSIn conclusion, SKTs from donors weighing ≤10 kg to adult recipients achieves comparable outcomes with EBKTs, which provides evidence to support performing SKTs from donors weighing ≤10 kg in certain donor and recipient scenarios.</description><identifier>ISSN: 2224-4336</identifier><identifier>ISSN: 2224-4344</identifier><identifier>EISSN: 2224-4344</identifier><identifier>DOI: 10.21037/tp-21-23</identifier><identifier>PMID: 34295776</identifier><language>eng</language><publisher>AME Publishing Company</publisher><subject>Original</subject><ispartof>Translational pediatrics, 2021-06, Vol.10 (6), p.1618-1629</ispartof><rights>2021 Translational Pediatrics. All rights reserved. 2021 Translational Pediatrics.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-f48f8a6dcaa2d2e3fbb53def7f9533fd8e40f0b82a787c936d6bd62eaa55d2093</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261586/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8261586/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Chen, Chuxiao</creatorcontrib><creatorcontrib>Su, Xiaojun</creatorcontrib><creatorcontrib>Wu, Chenglin</creatorcontrib><creatorcontrib>Liu, Longshan</creatorcontrib><creatorcontrib>Zhang, Huanxi</creatorcontrib><creatorcontrib>Deng, Ronghai</creatorcontrib><creatorcontrib>Fu, Qian</creatorcontrib><creatorcontrib>Yuan, Xiaopeng</creatorcontrib><creatorcontrib>Zheng, Yitao</creatorcontrib><creatorcontrib>Qiu, Jiang</creatorcontrib><creatorcontrib>Chen, Guodong</creatorcontrib><creatorcontrib>Huang, Gang</creatorcontrib><creatorcontrib>Deng, Suxiong</creatorcontrib><creatorcontrib>Fei, Jiguang</creatorcontrib><creatorcontrib>Chen, Lizhong</creatorcontrib><creatorcontrib>Li, Jun</creatorcontrib><creatorcontrib>Wang, Changxi</creatorcontrib><title>Successful single kidney transplantation from pediatric donors less than or equal to 10 kg to adult recipient: a retrospective cohort study</title><title>Translational pediatrics</title><description>BACKGROUNDKidneys from very small pediatric donors (≤10 kg) are underutilized. Compared to en bloc kidney transplantation (EBKT), single kidney transplantation (SKT) can maximize donor resources. However, it remains unknown whether it's appropriate to perform SKTs from donors weighing ≤10 kg. METHODSA total of 35 adult recipients undergoing kidney transplantation from donors weighing ≤10 kg at our center from December 2014 to December 2019 were included and grouped into SKT group (n=20) and EBKT group (n=15). Transplant outcomes were retrospectively analyzed and compared between 2 groups. RESULTSThe 1-year and 3-year death-censored graft survival in SKT group was 95%, it is not significantly higher than that in EBKT group (80%, log-rank test, P=0.38). Significant improvement in estimated glomerular filtration rate (eGFR) was noted in both groups, despite eGFR at 1 year was lower in the SKT group (P&lt;0.01). Proteinuria was common in both groups but subsided gradually during the follow-up time. Complication rates were similar between 2 groups with no vascular thrombosis in the SKT group. CONCLUSIONSIn conclusion, SKTs from donors weighing ≤10 kg to adult recipients achieves comparable outcomes with EBKTs, which provides evidence to support performing SKTs from donors weighing ≤10 kg in certain donor and recipient scenarios.</description><subject>Original</subject><issn>2224-4336</issn><issn>2224-4344</issn><issn>2224-4344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpVUctuFDEQtBCIRCEH_sBHOAzY7bFnlgMSinhJkTgAZ6vHbu-azNoT2xNpv4GfZiBRJE5dra6u6gdjL6V4A1Ko4W1bOpAdqCfsHAD6rld9__QRK3PGLmv9JYSQRksJ8JydqR52ehjMOfv9fXWOag3rzGtM-5n4TfSJTrwVTHWZMTVsMSceSj7yhXzEVqLjPqdcKp-3Xt4OmHgunG5XnHnLXAp-s_8L0K9z44VcXCKl9o7jlrSS60KuxTviLh9yaby21Z9esGcB50qXD_GC_fz08cfVl-762-evVx-uO6c0tC70YxjReIcIHkiFadLKUxjCTisV_Ei9CGIaAYdxcDtlvJm8AULU2oPYqQv2_l53WacjebcNVnC2S4lHLCebMdr_Kyke7D7f2RGM1KPZBF49CJR8u1Jt9hiro3k7FuW1WtBaS6H7ATbq63uq25auhcKjjRT23_9sWzZgQak_Rj-Q2g</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Chen, Chuxiao</creator><creator>Su, Xiaojun</creator><creator>Wu, Chenglin</creator><creator>Liu, Longshan</creator><creator>Zhang, Huanxi</creator><creator>Deng, Ronghai</creator><creator>Fu, Qian</creator><creator>Yuan, Xiaopeng</creator><creator>Zheng, Yitao</creator><creator>Qiu, Jiang</creator><creator>Chen, Guodong</creator><creator>Huang, Gang</creator><creator>Deng, Suxiong</creator><creator>Fei, Jiguang</creator><creator>Chen, Lizhong</creator><creator>Li, Jun</creator><creator>Wang, Changxi</creator><general>AME Publishing Company</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202106</creationdate><title>Successful single kidney transplantation from pediatric donors less than or equal to 10 kg to adult recipient: a retrospective cohort study</title><author>Chen, Chuxiao ; Su, Xiaojun ; Wu, Chenglin ; Liu, Longshan ; Zhang, Huanxi ; Deng, Ronghai ; Fu, Qian ; Yuan, Xiaopeng ; Zheng, Yitao ; Qiu, Jiang ; Chen, Guodong ; Huang, Gang ; Deng, Suxiong ; Fei, Jiguang ; Chen, Lizhong ; Li, Jun ; Wang, Changxi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-f48f8a6dcaa2d2e3fbb53def7f9533fd8e40f0b82a787c936d6bd62eaa55d2093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Original</topic><toplevel>online_resources</toplevel><creatorcontrib>Chen, Chuxiao</creatorcontrib><creatorcontrib>Su, Xiaojun</creatorcontrib><creatorcontrib>Wu, Chenglin</creatorcontrib><creatorcontrib>Liu, Longshan</creatorcontrib><creatorcontrib>Zhang, Huanxi</creatorcontrib><creatorcontrib>Deng, Ronghai</creatorcontrib><creatorcontrib>Fu, Qian</creatorcontrib><creatorcontrib>Yuan, Xiaopeng</creatorcontrib><creatorcontrib>Zheng, Yitao</creatorcontrib><creatorcontrib>Qiu, Jiang</creatorcontrib><creatorcontrib>Chen, Guodong</creatorcontrib><creatorcontrib>Huang, Gang</creatorcontrib><creatorcontrib>Deng, Suxiong</creatorcontrib><creatorcontrib>Fei, Jiguang</creatorcontrib><creatorcontrib>Chen, Lizhong</creatorcontrib><creatorcontrib>Li, Jun</creatorcontrib><creatorcontrib>Wang, Changxi</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Translational pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Chuxiao</au><au>Su, Xiaojun</au><au>Wu, Chenglin</au><au>Liu, Longshan</au><au>Zhang, Huanxi</au><au>Deng, Ronghai</au><au>Fu, Qian</au><au>Yuan, Xiaopeng</au><au>Zheng, Yitao</au><au>Qiu, Jiang</au><au>Chen, Guodong</au><au>Huang, Gang</au><au>Deng, Suxiong</au><au>Fei, Jiguang</au><au>Chen, Lizhong</au><au>Li, Jun</au><au>Wang, Changxi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful single kidney transplantation from pediatric donors less than or equal to 10 kg to adult recipient: a retrospective cohort study</atitle><jtitle>Translational pediatrics</jtitle><date>2021-06</date><risdate>2021</risdate><volume>10</volume><issue>6</issue><spage>1618</spage><epage>1629</epage><pages>1618-1629</pages><issn>2224-4336</issn><issn>2224-4344</issn><eissn>2224-4344</eissn><abstract>BACKGROUNDKidneys from very small pediatric donors (≤10 kg) are underutilized. Compared to en bloc kidney transplantation (EBKT), single kidney transplantation (SKT) can maximize donor resources. However, it remains unknown whether it's appropriate to perform SKTs from donors weighing ≤10 kg. METHODSA total of 35 adult recipients undergoing kidney transplantation from donors weighing ≤10 kg at our center from December 2014 to December 2019 were included and grouped into SKT group (n=20) and EBKT group (n=15). Transplant outcomes were retrospectively analyzed and compared between 2 groups. RESULTSThe 1-year and 3-year death-censored graft survival in SKT group was 95%, it is not significantly higher than that in EBKT group (80%, log-rank test, P=0.38). Significant improvement in estimated glomerular filtration rate (eGFR) was noted in both groups, despite eGFR at 1 year was lower in the SKT group (P&lt;0.01). Proteinuria was common in both groups but subsided gradually during the follow-up time. Complication rates were similar between 2 groups with no vascular thrombosis in the SKT group. CONCLUSIONSIn conclusion, SKTs from donors weighing ≤10 kg to adult recipients achieves comparable outcomes with EBKTs, which provides evidence to support performing SKTs from donors weighing ≤10 kg in certain donor and recipient scenarios.</abstract><pub>AME Publishing Company</pub><pmid>34295776</pmid><doi>10.21037/tp-21-23</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record>
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title Successful single kidney transplantation from pediatric donors less than or equal to 10 kg to adult recipient: a retrospective cohort study
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