A Multi-Dimensional Analysis of a Novel Approach for Wireless Stimulation

The elimination of integrated batteries in biomedical implants holds great promise for improving health outcomes in patients with implantable devices. However, despite extensive research in wireless power transfer, achieving efficient power transfer and effective operational range have remained a hi...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 2020-12, Vol.67 (12), p.3307-3316
Main Authors: Abiri, Parinaz, Yousefi, Alireza, Abiri, Arash, Gudapati, Varun, Ding, Yichen, Nguyen, Kim-Lien, Abiri, Ahmad, Markovic, Dejan, Tai, Yu-Chong, Hsiai, Tzung K.
Format: Article
Language:English
Subjects:
Diameters
Dimensional analysis
Energy dissipation
Feasibility studies
Finite element method
implantable cardiovascular devices
implantable medical devices
Implants
inductive power transfer
Inductive power transmission
Magnetic resonance imaging
Mathematical analysis
Medical devices
Misalignment
Pacemakers
Power efficiency
Power management
Stimulation
Stimulators
Surgical implants
Systems design
Transceivers
Wireless communication
Wireless medical devices
wireless pacemaker
Wireless power transfer
Wireless power transmission
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Summary:The elimination of integrated batteries in biomedical implants holds great promise for improving health outcomes in patients with implantable devices. However, despite extensive research in wireless power transfer, achieving efficient power transfer and effective operational range have remained a hindering challenge within anatomical constraints. Objective : We hereby demonstrate an intravascular wireless and batteryless microscale stimulator, designed for (1) low power dissipation via intermittent transmission and (2) reduced fixation mechanical burden via deployment to the anterior cardiac vein (ACV, ∼3.8 mm in diameter). Methods : We introduced a unique coil design circumferentially confined to a 3 mm diameter hollow-cylinder that was driven by a novel transmitter-based control architecture with improved power efficiency. Results : We examined wireless capacity using heterogenous bovine tissue, demonstrating >5 V stimulation threshold with up to 20 mm transmitter-receiver displacement and 20° of misalignment. Feasibility for human use was validated using Finite Element Method (FEM) simulation of the cardiac cycle, guided by pacer phantom-integrated Magnetic Resonance Images (MRI). Conclusion : This system design thus enabled sufficient wireless power transfer in the face of extensive stimulator miniaturization. Significance : Our successful feasibility studies demonstrated the capacity for minimally invasive deployment and low-risk fixation.
ISSN:0018-9294
1558-2531
DOI:10.1109/TBME.2020.2983443