GABPA Expression in Endometrial Carcinoma: A Prognostic Marker

Background. GA-binding protein A (GABPA), a transcription factor, is broadly involved in physiological and pathological processes. Several studies have investigated the relationship between GABPA expression level and outcomes of various malignancies. However, the function and clinicopathological sig...

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Bibliographic Details
Published in:Disease markers 2021, Vol.2021, p.5552614-9
Main Authors: Ma, Xiaoxue, Lin, Qianhan, Cui, Gongting, Zhao, Jing, Wei, Xuan, Li, Rui, Mao, Hongluan, Ma, Yanhui, Liu, Peishu, Pang, Yingxin
Format: Article
Language:English
Subjects:
Aged
Biomarkers, Tumor - metabolism
Cancer therapies
Carcinoma
Cell cycle
Chemotherapy
Correlation
Endometrial Neoplasms - metabolism
Endometrial Neoplasms - pathology
Endometrium
Female
GA-binding protein
GA-Binding Protein Transcription Factor - genetics
GABPa gene
Gene expression
Genomes
Histology
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Medical prognosis
Middle Aged
Pathology
Patients
Physiological effects
Prognosis
Protein A
Proteins
Radiation therapy
RNA, Messenger - genetics
Software
Statistical analysis
Statistical models
Surgery
Survival
Survival analysis
Tissue analysis
Tissues
Transcription factors
Uterine cancer
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Summary:Background. GA-binding protein A (GABPA), a transcription factor, is broadly involved in physiological and pathological processes. Several studies have investigated the relationship between GABPA expression level and outcomes of various malignancies. However, the function and clinicopathological significance of GABPA in endometrial carcinoma (EC) remain obscure. Methods. The GABPA mRNA expression in EC tissues and adjacent nonneoplastic tissues in the TCGA database was involved in our study. The protein expression of GABPA in 107 EC tissues and 15 normal endometrial tissues was detected by immunohistochemistry. Results. The GABPA expression was significantly downregulated in EC tissues compared with its expression in normal tissues (P
ISSN:0278-0240
1875-8630
DOI:10.1155/2021/5552614