Aquatic Training after Joint Immobilization in Rats Promotes Adaptations in Myotendinous Junctions

The myotendinous junction (MTJ) is the muscle-tendon interface and constitutes an integrated mechanical unit to force transmission. Joint immobilization promotes muscle atrophy via disuse, while physical exercise can be used as an adaptative stimulus. In this study, we aimed to investigate the compo...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-07, Vol.22 (13), p.6983
Main Authors: Rocha, Lara Caetano, Barbosa, Gabriela Klein, Pimentel Neto, Jurandyr, Jacob, Carolina dos Santos, Knudsen, Andreas B., Watanabe, Ii-Sei, Ciena, Adriano Polican
Format: Article
Language:English
Subjects:
Adaptation
Atrophy
Exercise
Fractal geometry
Fractals
Immobilization
Injuries
Joints (anatomy)
Morphology
Muscles
Physical exercise
Physical fitness
Rehabilitation
Sarcomeres
Ultrastructure
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Summary:The myotendinous junction (MTJ) is the muscle-tendon interface and constitutes an integrated mechanical unit to force transmission. Joint immobilization promotes muscle atrophy via disuse, while physical exercise can be used as an adaptative stimulus. In this study, we aimed to investigate the components of the MTJ and their adaptations and the associated elements triggered with aquatic training after joint immobilization. Forty-four male Wistar rats were divided into sedentary (SD), aquatic training (AT), immobilization (IM), and immobilization/aquatic training (IMAT) groups. The samples were processed to measure fiber area, nuclear fractal dimension, MTJ nuclear density, identification of telocytes, sarcomeres, and MTJ perimeter length. In the AT group, the maintenance of ultrastructure and elements in the MTJ region were observed; the IM group presented muscle atrophy effects with reduced MTJ perimeter; the IMAT group demonstrated that aquatic training after joint immobilization promotes benefits in the muscle fiber area and fractal dimension, in the MTJ region shows longer sarcomeres and MTJ perimeter. We identified the presence of telocytes in the MTJ region in all experimental groups. We concluded that aquatic training is an effective rehabilitation method after joint immobilization due to reduced muscle atrophy and regeneration effects on MTJ in rats.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22136983