Biodistribution of Mesenchymal Stromal Cells after Administration in Animal Models and Humans: A Systematic Review

Mesenchymal Stromal Cells (MSCs) are of great interest in cellular therapy. Different routes of administration of MSCs have been described both in pre-clinical and clinical reports. Knowledge about the fate of the administered cells is critical for developing MSC-based therapies. The aim of this rev...

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Bibliographic Details
Published in:Journal of clinical medicine 2021-06, Vol.10 (13), p.2925
Main Authors: Sanchez-Diaz, Manuel, Quiñones-Vico, Maria I., Sanabria de la Torre, Raquel, Montero-Vílchez, Trinidad, Sierra-Sánchez, Alvaro, Molina-Leyva, Alejandro, Arias-Santiago, Salvador
Format: Article
Language:English
Subjects:
Adipocytes
Alzheimer's disease
Biodistribution
Clinical medicine
Heart attacks
Kidneys
Liver
Lungs
Review
Spinal cord
Stem cells
Systematic review
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Summary:Mesenchymal Stromal Cells (MSCs) are of great interest in cellular therapy. Different routes of administration of MSCs have been described both in pre-clinical and clinical reports. Knowledge about the fate of the administered cells is critical for developing MSC-based therapies. The aim of this review is to describe how MSCs are distributed after injection, using different administration routes in animal models and humans. A literature search was performed in order to consider how MSCs distribute after intravenous, intraarterial, intramuscular, intraarticular and intralesional injection into both animal models and humans. Studies addressing the biodistribution of MSCs in “in vivo” animal models and humans were included. After the search, 109 articles were included in the review. Intravenous administration of MSCs is widely used; it leads to an initial accumulation of cells in the lungs with later redistribution to the liver, spleen and kidneys. Intraarterial infusion bypasses the lungs, so MSCs distribute widely throughout the rest of the body. Intramuscular, intraarticular and intradermal administration lack systemic biodistribution. Injection into various specific organs is also described. Biodistribution of MSCs in animal models and humans appears to be similar and depends on the route of administration. More studies with standardized protocols of MSC administration could be useful in order to make results homogeneous and more comparable.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10132925