Effects of concentrated ambient ultrafine particulate matter on hallmarks of Alzheimer’s disease in the 3xTgAD mouse model

•Concentrated UFP exposure did not cause overt lung inflammation.•UFP exposure in 3xTgAD mice led to perturbations in microglia morphology.•3xTgAD mice exposed to UFP had elevated levels of phospho-tau immunoreactivity.•UFP-exposed 3xTgAD mice had decreased amyloid deposition. Exposure to air pollut...

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Bibliographic Details
Published in:Neurotoxicology (Park Forest South) 2021-05, Vol.84, p.172-183
Main Authors: Herr, Denise, Jew, Katrina, Wong, Candace, Kennell, Andrea, Gelein, Robert, Chalupa, David, Raab, Alexandria, Oberdörster, Günter, Olschowka, John, O’Banion, M. Kerry, Elder, Alison
Format: Article
Language:English
Subjects:
Air pollution
Air Pollution - adverse effects
Air pollution measurements
Alzheimer Disease - chemically induced
Alzheimer Disease - genetics
Alzheimer Disease - metabolism
Alzheimer's disease
Amyloid
Amyloid-β
Animals
Brain - drug effects
Brain - metabolism
Bronchus
Calcium
Cell morphology
Cytology
Disease Models, Animal
Exposure
Genotype & phenotype
Genotypes
Glial fibrillary acidic protein
Health risks
Hippocampus
Inflammation
Inhalation exposure
Inhalation Exposure - adverse effects
Lung - drug effects
Lung - metabolism
Lungs
Male
Markers
Mice
Mice, 129 Strain
Mice, Transgenic
Microglia
Microglia - drug effects
Microglia - metabolism
Morphology
Neurodegenerative diseases
Particle Size
Particulate matter
Particulate Matter - administration & dosage
Particulate Matter - toxicity
Particulates
Pathology
Phosphorylation
Plaques
Proteins
Staining
Tau
Tau protein
tau Proteins - metabolism
Ultrafine particles
Ultrafines
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Summary:•Concentrated UFP exposure did not cause overt lung inflammation.•UFP exposure in 3xTgAD mice led to perturbations in microglia morphology.•3xTgAD mice exposed to UFP had elevated levels of phospho-tau immunoreactivity.•UFP-exposed 3xTgAD mice had decreased amyloid deposition. Exposure to air pollution has been identified as a possible environmental contributor to Alzheimer’s Disease (AD) risk. As the number of people with AD worldwide continues to rise, it becomes vital to understand the nature of this potential gene-environment interaction. This study assessed the effects of short-term exposures to concentrated ambient ultrafine particulates (UFP,
ISSN:0161-813X
1872-9711
DOI:10.1016/j.neuro.2021.03.010