Prognostic Factors for Wilms Tumor Recurrence: A Review of the Literature

In high-income countries, the overall survival of children with Wilms tumors (WT) is ~90%. However, overall, 15% of patients experience tumor recurrence. The adverse prognostic factors currently used for risk stratification (advanced stage, high risk histology, and combined loss of heterozygosity at...

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Bibliographic Details
Published in:Cancers 2021-06, Vol.13 (13), p.3142
Main Authors: Groenendijk, Alissa, Spreafico, Filippo, de Krijger, Ronald R., Drost, Jarno, Brok, Jesper, Perotti, Daniela, van Tinteren, Harm, Venkatramani, Rajkumar, Godziński, Jan, Rübe, Christian, Geller, James I., Graf, Norbert, van den Heuvel-Eibrink, Marry M., Mavinkurve-Groothuis, Annelies M. C.
Format: Article
Language:English
Subjects:
Age
Biomarkers
Chemotherapy
Children
Classification
Copy number
Heterozygosity
Histology
Literature reviews
Loss of heterozygosity
Medical prognosis
Oncology
Patients
Pediatrics
Radiation therapy
Review
Socioeconomic factors
Tumors
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Summary:In high-income countries, the overall survival of children with Wilms tumors (WT) is ~90%. However, overall, 15% of patients experience tumor recurrence. The adverse prognostic factors currently used for risk stratification (advanced stage, high risk histology, and combined loss of heterozygosity at 1p and 16q in chemotherapy-naïve WTs) are present in only one third of these cases, and the significance of these factors is prone to change with advancing knowledge and improved treatment regimens. Therefore, we present a comprehensive, updated overview of the published prognostic variables for WT recurrence, ranging from patient-, tumor- and treatment-related characteristics to geographic and socioeconomic factors. Improved first-line treatment regimens based on clinicopathological characteristics and advancing knowledge on copy number variations unveil the importance of further investigating the significance of biological markers for WT recurrence in international collaborations.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13133142