Soluble C-Type Lectin-Like Receptor 2 Is a Biomarker for Disseminated Intravascular Coagulation

Disseminated intravascular coagulation (DIC) is induced by excess activation coagulation, and activated platelets are also involved in pathogenesis. Therefore, plasma levels of soluble C-type lectin-like receptor 2 (sCLEC-2), a new marker for platelet activation, can be expected as a marker of DIC i...

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Published in:Journal of clinical medicine 2021-06, Vol.10 (13), p.2860
Main Authors: Yamamoto, Akitaka, Wada, Hideo, Ichkawa, Yuhuko, Tanaka, Motoko, Tashiro, Haruhiko, Shiraki, Katsuya, Shimpo, Hideto, Yamashita, Yoshiki, Mastumoto, Takeshi, Shimaoka, Motomu, Iba, Toshiaki, Suzuki-Inoue, Katsue
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Aortic aneurysms
Biomarkers
Blood platelets
Cancer therapies
Clinical medicine
Disease
Hypothermia
Infections
Laboratories
Monoclonal antibodies
Obstetrics
Patients
Plasma
Thrombosis
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Summary:Disseminated intravascular coagulation (DIC) is induced by excess activation coagulation, and activated platelets are also involved in pathogenesis. Therefore, plasma levels of soluble C-type lectin-like receptor 2 (sCLEC-2), a new marker for platelet activation, can be expected as a marker of DIC in critically ill patients. Plasma levels of sCLEC-2 and D-dimer were measured using the STACIA system. Plasma sCLEC-2 and D-dimer levels were significantly higher in patients with underlying diseases of DIC than in those with unidentified clinical syndrome (UCS). Plasma sCLEC-2 levels were significantly higher in the patients with DIC and Pre-DIC than in those without DIC or Pre-DIC. Similarly, plasma D-dimer levels were also significantly higher in patients with DIC and Pre-DIC than in those without DIC or Pre-DIC. The plasma sCLEC-2 levels in all patients and those with a DIC score ≤ 4 were significantly higher in non-survivors than survivors. The plasma D-dimer levels in all patients, those with a DIC score ≥ 5 and those with a DIC score ≤ 4, were significantly higher in non-survivors than in survivors. The plasma sCLEC-2 is expected as a marker for DIC/Pre-DIC as well as the prognostic marker in critically ill patients.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10132860