Alterations in Rev-ERBα/BMAL1 ratio and glycated hemoglobin in rotating shift workers: the EuRhythDia study

Objective To detect premature gluco-metabolic defects among night shift workers with disturbances in circadian rhythms. Design and methods We performed a hypothesis-generating, cross-sectional analysis of anthropometric, metabolic, lipid, and inflammation parameters, comparing active (a-NSW, n  = 11...

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Bibliographic Details
Published in:Acta diabetologica 2021-08, Vol.58 (8), p.1111-1117
Main Authors: Rizza, Stefano, Luzi, Alessio, Mavilio, Maria, Ballanti, Marta, Massimi, Arianna, Porzio, Ottavia, Magrini, Andrea, Hannemann, Juliane, Menghini, Rossella, Lehrke, Michael, Staels, Bart, Grant, Peter J., Boger, Rainer H., Marx, Nikolaus, Federici, Massimo
Format: Article
Language:English
Subjects:
Adult
ARNTL Transcription Factors - blood
ARNTL Transcription Factors - genetics
Blood
Blood Pressure
BMAL1 protein
Circadian Rhythm - genetics
Circadian Rhythm - physiology
Circadian rhythms
Clock gene
Cross-Sectional Studies
Diabetes
Female
Gene Expression
Glycated Hemoglobin - analysis
Hemoglobin
Hospitals
Humans
Inflammation
Internal Medicine
Leukocyte Count
Leukocytes (mononuclear)
Leukocytes, Mononuclear - chemistry
Leukocytes, Mononuclear - metabolism
Male
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolism
Middle Aged
Nighttime
Nuclear Receptor Subfamily 1, Group D, Member 1 - blood
Nuclear Receptor Subfamily 1, Group D, Member 1 - genetics
Nurses
Original
Original Article
Peripheral blood mononuclear cells
RNA - blood
Shift Work Schedule
Sleep - physiology
Sleep deprivation
Transcription factors
Workers
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Summary:Objective To detect premature gluco-metabolic defects among night shift workers with disturbances in circadian rhythms. Design and methods We performed a hypothesis-generating, cross-sectional analysis of anthropometric, metabolic, lipid, and inflammation parameters, comparing active (a-NSW, n  = 111) and former (f-NSW, n  = 98) rotating night shift workers with diurnal workers (controls, n  = 69). All participants were hospital nurses. We also evaluated the Pittsburgh Sleep Quality Index (PSQI) and assessed expression of transcription factors REV-ERBα and BMAL1 in peripheral blood mononuclear cells (PBMCs), as indicators of the molecular clock. Results Both a-NSW and f-NSW participants had significantly higher glycated hemoglobin (HbA1c) and white blood cell counts (WBC) ( p  
ISSN:0940-5429
1432-5233
DOI:10.1007/s00592-021-01676-z