Evidence for human diabetic cardiomyopathy

Growing interest has been accumulated in the definition of worsening effects of diabetes in the cardiovascular system. This is associated with epidemiological data regarding the high incidence of heart failure (HF) in diabetic patients. To investigate the detrimental effects both of hyperglycemia an...

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Bibliographic Details
Published in:Acta diabetologica 2021-08, Vol.58 (8), p.983-988
Main Authors: Marfella, Raffaele, Sardu, Celestino, Mansueto, Gelsomina, Napoli, Claudio, Paolisso, Giuseppe
Format: Article
Language:English
Subjects:
Cardiomyopathy
Cardiovascular system
Congestive heart failure
Diabetes
Diabetes mellitus
Epidemiology
Fibrosis
Hyperglycemia
Insulin
Insulin resistance
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Review
Review Article
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Summary:Growing interest has been accumulated in the definition of worsening effects of diabetes in the cardiovascular system. This is associated with epidemiological data regarding the high incidence of heart failure (HF) in diabetic patients. To investigate the detrimental effects both of hyperglycemia and insulin resistance, a lot of preclinical models were developed. However, the evidence of pathogenic and histological alterations of the so-called diabetic cardiomyopathy (DCM) is still poorly understood in humans. Here, we provide a stringent literature analysis to investigate unique data regarding human DCM. This approach established that lipotoxic-related events might play a central role in the initiation and progression of human DCM. The major limitation in the acquisition of human data is due to the fact of heart specimen availability. Postmortem analysis revealed the end stage of the disease; thus, we need to gain knowledge on the pathogenic events from the early stages until cardiac fibrosis underlying the end-stage HF.
ISSN:0940-5429
1432-5233
DOI:10.1007/s00592-021-01705-x