Major urinary protein excreted in rodent hindpaw sweat

Alternative roles for sweat production beyond thermoregulation, considered less frequently, include chemical signaling. We identified the presence of a well‐established rodent urinary pheromone, major urinary protein (MUP) in sweat ductules of the footpad dermal skin of mice. A hindpaw sweat proteom...

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Bibliographic Details
Published in:Journal of anatomy 2021-08, Vol.239 (2), p.529-535
Main Authors: Poitras, Trevor, Piragasam, Ramanaguru Siva, Joy, Twinkle, Jackson, Jesse, Chandrasekhar, Ambika, Fahlman, Richard, Zochodne, Douglas W.
Format: Article
Language:English
Subjects:
Animal Communication
Animals
Brief Communication
Chemical communication
Hindlimb
Lipocalin
lipocalins
Lysates
Male
Mice
MUPs (major urinary proteins)
pheromone
Proteins
Proteins - metabolism
Rats
Rats, Sprague-Dawley
Sweat
Sweat - metabolism
Sweat gland
sweat glands
Thermoregulation
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Summary:Alternative roles for sweat production beyond thermoregulation, considered less frequently, include chemical signaling. We identified the presence of a well‐established rodent urinary pheromone, major urinary protein (MUP) in sweat ductules of the footpad dermal skin of mice. A hindpaw sweat proteomic analysis in hindpaw sweat samples collected in rats and generated by unmyelinated axon activation, identified seven lipocalin family members including MUP and 19 additional unique proteins. Behavioural responses to sniffing male mouse foot protein lysates suggested avoidance in a subset of male mice, but were not definitive. Rodent hindpaw sweat glands secrete a repertoire of proteins that include MUPs known to have roles in olfactory communication. Dermal sweat gland in the hindpaw of a mouse that expresses MUP protein. MUPs were detected in mouse and rat hindpaw sweat samples and accompanied a sweat proteome.
ISSN:0021-8782
1469-7580
DOI:10.1111/joa.13423