The Potential Benefits of Nanotechnology in Treating Alzheimer’s Disease

Alzheimer’s disease is a neurodegenerative disorder that is caused by the accumulation of beta-amyloid plaques in the brain. Currently, there is no definitive cure available to treat Alzheimer’s disease. The available medication in the market has the ability to only slow down its progression. Howeve...

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Bibliographic Details
Published in:BioMed research international 2021, Vol.2021, p.5550938-9
Main Authors: Ling, Tan Sook, Chandrasegaran, Shanthini, Xuan, Low Zhi, Suan, Tong Li, Elaine, Elaine, Nathan, Durrgashini Visva, Chai, Yam Hok, Gunasekaran, Baskaran, Salvamani, Shamala
Format: Article
Language:English
Subjects:
Alzheimer Disease - genetics
Alzheimer Disease - immunology
Alzheimer Disease - therapy
Alzheimer's disease
Analysis
Animals
Antioxidants
Bioavailability
Blood-brain barrier
Care and treatment
Dementia
Diagnosis
Drug delivery
Drug Delivery Systems
Drugs
Evaluation
Gene therapy
Genetic Therapy
Health services
Humans
Immunotherapy
Metabolism
Methods
Mitochondria
Nanomaterials
Nanomedicine
Nanoparticles - therapeutic use
Nanotechnology
Neurodegenerative diseases
Neuroprotection
Older people
Peptides
Proteins
Regeneration
Regenerative medicine
Review
Senile plaques
Stem cells
Toxicity
Vehicles
β-Amyloid
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Description
Summary:Alzheimer’s disease is a neurodegenerative disorder that is caused by the accumulation of beta-amyloid plaques in the brain. Currently, there is no definitive cure available to treat Alzheimer’s disease. The available medication in the market has the ability to only slow down its progression. However, nanotechnology has shown its superiority that can be applied for medical usage and it has a great potential in the therapy of Alzheimer’s disease, specifically in the disease diagnosis and providing an alternative approach to treat Alzheimer’s disease. This is done by increasing the efficiency of drug delivery by penetrating and overcoming the blood-brain barrier. Having said that, there are limitations that need to be further investigated and researched in order to minimize the adverse effects and potential toxicity and to improve drug bioavailability. The recent advances in the treatment of Alzheimer’s disease using nanotechnology include the regeneration of stem cells, nanomedicine, and neuroprotection. In this review, we will discuss the advancement of nanotechnology which helps in the diagnosis and treatment of neurodegenerative disorders such as Alzheimer’s disease as well as its challenges.
ISSN:2314-6133
2314-6141
2314-6141
DOI:10.1155/2021/5550938