Dose-related and contextual aspects of suboptimal adherence to antiretroviral therapy among persons living with HIV in Western Europe

Abstract Background The daily oral dosing requirement for antiretroviral therapy (ART) may be challenging for some people living with HIV (PLWHIV) with comorbid conditions, confidentiality concerns or pill fatigue. We investigated suboptimal adherence from the perspective of PLWHIV and HIV physician...

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Bibliographic Details
Published in:European journal of public health 2021-06, Vol.31 (3), p.567-575
Main Authors: Akinwunmi, Babatunde, Buchenberger, Daniel, Scherzer, Jenny, Bode, Martina, Rizzini, Paolo, Vecchio, Fabio, Roustand, Laetitia, Nachbaur, Gaelle, Finkielsztejn, Laurent, Chounta, Vasiliki, Van de Velde, Nicolas
Format: Article
Language:English
Subjects:
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Antiviral agents
Anxiety
Cognition
Complications and side effects
Confidentiality
Dosage
Dosage and administration
Drug therapy
Dysphagia
HIV
HIV patients
Human immunodeficiency virus
Infectious Diseases
Management
Medical treatment
Mental disorders
Mental health
Patient compliance
Patients
Physicians
Public health
Schedules
Side effects
Surveys
Therapy
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Summary:Abstract Background The daily oral dosing requirement for antiretroviral therapy (ART) may be challenging for some people living with HIV (PLWHIV) with comorbid conditions, confidentiality concerns or pill fatigue. We investigated suboptimal adherence from the perspective of PLWHIV and HIV physicians. Methods PLWHIV on ART (n = 688) and HIV physicians (n = 120) were surveyed during 2019 in France, Germany, Italy and the UK. Suboptimal adherence was a report the participant missed taking their dose as prescribed ‘Sometimes’/‘Often’/‘Very often’. Physicians’ interest in offering a hypothetical long-acting HIV regimen for suboptimally adherent patients was assessed. Descriptive and multivariable analyses were performed (P 
ISSN:1101-1262
1464-360X
DOI:10.1093/eurpub/ckaa229