Gridlock from Diagnosis to Treatment of Multidrug-Resistant Tuberculosis (MDR-TB) in Tanzania: Illuminating Potential Factors for Possible Intervention

SETTINGSKibong'oto Infectious Diseases Hospital, Kilimanjaro, Tanzania. OBJECTIVECharacterise multidrug-resistant tuberculosis (MDR-TB)-treated cases during the scaling up of molecular diagnostics using Xpert MTB/RIF and GenoType MTBDRplus. DESIGNRetrospective cohort study. RESULTSA total of 22...

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Published in:The East African health research journal 2017-01, Vol.1 (1), p.31-39
Main Authors: Liyoyo, Alphonce, Heysell, Scott, Kisonga, Riziki, Lyimo, Johnson, Mleoh, Liberate, Mutayoba, Beatrice, Lekule, Isaack, Mmbaga, Blandina, Kibiki, Gibson, Mpagama, Stellah
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Language:English
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Summary:SETTINGSKibong'oto Infectious Diseases Hospital, Kilimanjaro, Tanzania. OBJECTIVECharacterise multidrug-resistant tuberculosis (MDR-TB)-treated cases during the scaling up of molecular diagnostics using Xpert MTB/RIF and GenoType MTBDRplus. DESIGNRetrospective cohort study. RESULTSA total of 223 MDR-TB patients were referred to the Kibong'oto Infectious Disease Hospital from January 2013 through December 2014. Four cities-Dar es Salaam, Mbeya, Mwanza, and Tanga-contributed 144 (65%) of referrals. Of the total referred patients, HIV coinfection was found in 92 (41%) and 180 (81%) had history of previous TB treatment. Molecular drug susceptibility testing (DST) contributed 201 (91%) of referrals and resulted in a shorter time from diagnosis to start of treatment, 30 days (95% confidence interval [CI], 26-37), compared to conventional phenotypic DST, 212 days (95% CI, 151-272; P
ISSN:2520-5277
2520-5277
2520-5285
DOI:10.24248/EAHRJ-D-16-00330