Pathomechanisms and possible interventions in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease with unknown etiology, no validated specific and sensitive biomarker, and no standard approved effective treatment. ME/CFS has a profound impact on the quality of life of both patients and caregivers and entails high costs for...

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Bibliographic Details
Published in:The Journal of clinical investigation 2021-07, Vol.131 (14), p.1-4
Main Authors: Fluge, Oystein, Tronstad, Karl J, Mella, Olav
Format: Article
Language:English
Subjects:
Adaptation
Anaerobic threshold
Autoimmune diseases
Autoimmunity
Biomedical research
Blood flow
Cancer therapies
Care and treatment
Chronic fatigue syndrome
Development and progression
Disease
Encephalomyelitis
Etiology
Fatigue
Gene expression
Health aspects
Homeostasis
Hypoxia
Immobilization
Immune response
Kinases
Metabolism
Patients
Plasma
Quality of life
Veins & arteries
Viewpoint
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Description
Summary:Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease with unknown etiology, no validated specific and sensitive biomarker, and no standard approved effective treatment. ME/CFS has a profound impact on the quality of life of both patients and caregivers and entails high costs for society. The severity varies among patients who are able to participate to some extent in social life (mild), those who are mainly housebound (moderate) or bedridden (severe), and the very severely ill who are completely dependent on assistance for all daily living tasks, such as feeding or turning around in bed. Here, Fluge et al suggest a framework model for the initiation and maintenance of ME/CFS consisting of three principal steps: an initial aberrant immune response; an effector system for symptom generation and maintenance; and compensatory adaptations.
ISSN:1558-8238
0021-9738
1558-8238
DOI:10.1172/JCI150377