The Prognostic Value of Leucine-Rich α2 Glycoprotein 1 in Pediatric Spinal Cord Injury

Objective. Leucine-rich α2 glycoprotein 1 (LRG1) is a novel cytokine, which is believed to be involved in the inflammatory process of a series of diseases. However, the relationship between LRG1 and spinal cord injury (SCI) has not been reported. The purpose of our study is to determine the predicti...

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Published in:BioMed research international 2021-01, Vol.2021 (1), p.7365204-7365204
Main Authors: Ma, Hong, Lu, Fengshan, Guo, Yueming, Shen, Zhaoxiong, Chen, Yuanzhen
Format: Article
Language:English
Subjects:
Age
Biomarkers
Blood pressure
Body temperature
C-reactive protein
Chinese medicine
Cytokines
Gender
Glycoproteins
Heart rate
Herbal medicine
Inflammation
International standards
Leucine
Leukocytes
Patients
Pediatrics
Peripheral blood
Prognosis
Proteins
Reagents
Spinal cord injuries
Traditional Chinese medicine
Variables
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creator Ma, Hong
Lu, Fengshan
Guo, Yueming
Shen, Zhaoxiong
Chen, Yuanzhen
description Objective. Leucine-rich α2 glycoprotein 1 (LRG1) is a novel cytokine, which is believed to be involved in the inflammatory process of a series of diseases. However, the relationship between LRG1 and spinal cord injury (SCI) has not been reported. The purpose of our study is to determine the predictive value of LRG1 for the prognosis of pediatric SCI (PSCI). Methods. This study recruited 64 patients with confirmed PSCI and 40 healthy controls at Foshan Traditional Chinese Medicine Hospital from January 2016 to December 2020. The clinical information of all participants at the time of admission was recorded. Peripheral blood was collected, and commercial reagents were used to detect the level of serum LRG1. At the same time, the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) was used to assess the severity of PSCI. Results. All participants were divided into PSCI group (n=64) and NC group (n=40). There was no significant difference in clinical information (age, gender, heart rate, systolic blood pressure, diastolic blood pressure, sampling time from injury, white blood cells, and C-reactive protein) between the two groups (p>0.05). According to the interquartile range of serum LRG1, we compared the motor and sensory scores of ISNCSCI and found that serum LRG1 levels were negatively correlated with the prognosis of PSCI patients (p
doi_str_mv 10.1155/2021/7365204
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Leucine-rich α2 glycoprotein 1 (LRG1) is a novel cytokine, which is believed to be involved in the inflammatory process of a series of diseases. However, the relationship between LRG1 and spinal cord injury (SCI) has not been reported. The purpose of our study is to determine the predictive value of LRG1 for the prognosis of pediatric SCI (PSCI). Methods. This study recruited 64 patients with confirmed PSCI and 40 healthy controls at Foshan Traditional Chinese Medicine Hospital from January 2016 to December 2020. The clinical information of all participants at the time of admission was recorded. Peripheral blood was collected, and commercial reagents were used to detect the level of serum LRG1. At the same time, the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) was used to assess the severity of PSCI. Results. All participants were divided into PSCI group (n=64) and NC group (n=40). There was no significant difference in clinical information (age, gender, heart rate, systolic blood pressure, diastolic blood pressure, sampling time from injury, white blood cells, and C-reactive protein) between the two groups (p&gt;0.05). According to the interquartile range of serum LRG1, we compared the motor and sensory scores of ISNCSCI and found that serum LRG1 levels were negatively correlated with the prognosis of PSCI patients (p&lt;0.001). The results of receiver operating curve (ROC) showed that the sensitivity, specificity, and AUC (Area Under the Curve) of serum LRG1 level in predicting the prognosis of PSCI were 68.4%, 69.1%, and 0.705, respectively. The cut-off value of serum LRG1 level predicting the prognosis of PSCI is 21.1 μg/ml. Conclusions. Serum LRG1 level is significantly increased in PSCI patients, and the elevated LRG1 level is negatively correlated with the prognosis of PSCI patients. Serum LRG1 may be a potentially useful biomarker for predicting PSCI.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2021/7365204</identifier><identifier>PMID: 34307668</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>Age ; Biomarkers ; Blood pressure ; Body temperature ; C-reactive protein ; Chinese medicine ; Cytokines ; Gender ; Glycoproteins ; Heart rate ; Herbal medicine ; Inflammation ; International standards ; Leucine ; Leukocytes ; Patients ; Pediatrics ; Peripheral blood ; Prognosis ; Proteins ; Reagents ; Spinal cord injuries ; Traditional Chinese medicine ; Variables</subject><ispartof>BioMed research international, 2021-01, Vol.2021 (1), p.7365204-7365204</ispartof><rights>Copyright © 2021 Hong Ma et al.</rights><rights>Copyright © 2021 Hong Ma et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Hong Ma et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-2e5ac997c533160e8eb72c7dc3c633473042a9a471b15c65f52585797203a6fe3</citedby><cites>FETCH-LOGICAL-c355t-2e5ac997c533160e8eb72c7dc3c633473042a9a471b15c65f52585797203a6fe3</cites><orcidid>0000-0003-3513-2268 ; 0000-0002-6776-8634 ; 0000-0003-1167-4708</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2552746674/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2552746674?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,25753,27924,27925,37012,37013,44590,74998</link.rule.ids></links><search><contributor>Xu, Yuzhen</contributor><contributor>Yuzhen Xu</contributor><creatorcontrib>Ma, Hong</creatorcontrib><creatorcontrib>Lu, Fengshan</creatorcontrib><creatorcontrib>Guo, Yueming</creatorcontrib><creatorcontrib>Shen, Zhaoxiong</creatorcontrib><creatorcontrib>Chen, Yuanzhen</creatorcontrib><title>The Prognostic Value of Leucine-Rich α2 Glycoprotein 1 in Pediatric Spinal Cord Injury</title><title>BioMed research international</title><description>Objective. Leucine-rich α2 glycoprotein 1 (LRG1) is a novel cytokine, which is believed to be involved in the inflammatory process of a series of diseases. However, the relationship between LRG1 and spinal cord injury (SCI) has not been reported. The purpose of our study is to determine the predictive value of LRG1 for the prognosis of pediatric SCI (PSCI). Methods. This study recruited 64 patients with confirmed PSCI and 40 healthy controls at Foshan Traditional Chinese Medicine Hospital from January 2016 to December 2020. The clinical information of all participants at the time of admission was recorded. Peripheral blood was collected, and commercial reagents were used to detect the level of serum LRG1. At the same time, the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) was used to assess the severity of PSCI. Results. All participants were divided into PSCI group (n=64) and NC group (n=40). There was no significant difference in clinical information (age, gender, heart rate, systolic blood pressure, diastolic blood pressure, sampling time from injury, white blood cells, and C-reactive protein) between the two groups (p&gt;0.05). According to the interquartile range of serum LRG1, we compared the motor and sensory scores of ISNCSCI and found that serum LRG1 levels were negatively correlated with the prognosis of PSCI patients (p&lt;0.001). The results of receiver operating curve (ROC) showed that the sensitivity, specificity, and AUC (Area Under the Curve) of serum LRG1 level in predicting the prognosis of PSCI were 68.4%, 69.1%, and 0.705, respectively. The cut-off value of serum LRG1 level predicting the prognosis of PSCI is 21.1 μg/ml. Conclusions. Serum LRG1 level is significantly increased in PSCI patients, and the elevated LRG1 level is negatively correlated with the prognosis of PSCI patients. 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Leucine-rich α2 glycoprotein 1 (LRG1) is a novel cytokine, which is believed to be involved in the inflammatory process of a series of diseases. However, the relationship between LRG1 and spinal cord injury (SCI) has not been reported. The purpose of our study is to determine the predictive value of LRG1 for the prognosis of pediatric SCI (PSCI). Methods. This study recruited 64 patients with confirmed PSCI and 40 healthy controls at Foshan Traditional Chinese Medicine Hospital from January 2016 to December 2020. The clinical information of all participants at the time of admission was recorded. Peripheral blood was collected, and commercial reagents were used to detect the level of serum LRG1. At the same time, the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) was used to assess the severity of PSCI. Results. All participants were divided into PSCI group (n=64) and NC group (n=40). There was no significant difference in clinical information (age, gender, heart rate, systolic blood pressure, diastolic blood pressure, sampling time from injury, white blood cells, and C-reactive protein) between the two groups (p&gt;0.05). According to the interquartile range of serum LRG1, we compared the motor and sensory scores of ISNCSCI and found that serum LRG1 levels were negatively correlated with the prognosis of PSCI patients (p&lt;0.001). The results of receiver operating curve (ROC) showed that the sensitivity, specificity, and AUC (Area Under the Curve) of serum LRG1 level in predicting the prognosis of PSCI were 68.4%, 69.1%, and 0.705, respectively. The cut-off value of serum LRG1 level predicting the prognosis of PSCI is 21.1 μg/ml. Conclusions. Serum LRG1 level is significantly increased in PSCI patients, and the elevated LRG1 level is negatively correlated with the prognosis of PSCI patients. Serum LRG1 may be a potentially useful biomarker for predicting PSCI.</abstract><cop>New York</cop><pub>Hindawi</pub><pmid>34307668</pmid><doi>10.1155/2021/7365204</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-3513-2268</orcidid><orcidid>https://orcid.org/0000-0002-6776-8634</orcidid><orcidid>https://orcid.org/0000-0003-1167-4708</orcidid><oa>free_for_read</oa></addata></record>
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subjects Age
Biomarkers
Blood pressure
Body temperature
C-reactive protein
Chinese medicine
Cytokines
Gender
Glycoproteins
Heart rate
Herbal medicine
Inflammation
International standards
Leucine
Leukocytes
Patients
Pediatrics
Peripheral blood
Prognosis
Proteins
Reagents
Spinal cord injuries
Traditional Chinese medicine
Variables
title The Prognostic Value of Leucine-Rich α2 Glycoprotein 1 in Pediatric Spinal Cord Injury
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