Post-translational modification of KRAS: potential targets for cancer therapy

Aberrant activation of the RAS superfamily is one of the critical factors in carcinogenesis. Among them, KRAS is the most frequently mutated one which has inspired extensive studies for developing approaches to intervention. Although the cognition toward KRAS remains far from complete, mounting evid...

Full description

Saved in:
Bibliographic Details
Published in:Acta pharmacologica Sinica 2021-08, Vol.42 (8), p.1201-1211
Main Authors: Wang, Wei-hua, Yuan, Tao, Qian, Mei-jia, Yan, Fang-jie, Yang, Liu, He, Qiao-jun, Yang, Bo, Lu, Jin-jian, Zhu, Hong
Format: Article
Language:English
Subjects:
Acetylation
Amino Acid Sequence
Animals
Antitumor agents
Biomedical and Life Sciences
Biomedicine
Cancer therapies
Carcinogenesis
Cognition
Humans
Immunology
Internal Medicine
K-Ras protein
Kinases
Laboratories
Localization
Medical Microbiology
Mutation
Palmitoylation
Pharmacology/Toxicology
Phosphorylation
Plasma
Post-translation
Protein Processing, Post-Translational - drug effects
Protein Processing, Post-Translational - physiology
Proteins
Proto-Oncogene Proteins p21(ras) - metabolism
Review
Review Article
SUMO protein
Translation
Ubiquitination
Vaccine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aberrant activation of the RAS superfamily is one of the critical factors in carcinogenesis. Among them, KRAS is the most frequently mutated one which has inspired extensive studies for developing approaches to intervention. Although the cognition toward KRAS remains far from complete, mounting evidence suggests that a variety of post-translational modifications regulate its activation and localization. In this review, we summarize the regulatory mode of post-translational modifications on KRAS including prenylation, post-prenylation, palmitoylation, ubiquitination, phosphorylation, SUMOylation, acetylation, nitrosylation, etc. We also highlight the recent studies targeting these modifications having exhibited potent anti-tumor activities.
ISSN:1671-4083
1745-7254
DOI:10.1038/s41401-020-00542-y