Epidemiology of cytomegalovirus Infection among mothers and infants in Colombia

• Published in: Journal of medical virology 2021-11, Vol.93 (11), p.6393-6397
• Main Authors: Rico, Angelica, Dollard, Sheila C., Valencia, Diana, Corchuelo, Sheryll, Tong, Van T., Laiton‐Donato, Katherine, Amin, Minal M., Benavides, Monica, Wong, Phili, Newton, Suzanne, Daza, Marcela, Cates, Jordan, Gonzalez, Maritza, Zambrano, Laura D., Mercado, Marcela M., Ailes, Elizabeth C., Rodriguez, Helena M., Gilboa, Suzanne M., Acosta, Jacqueline, Ricaldi, Jessica, Pelaez, Dioselina, Honein, Margaret A., Ospina, Martha L., Lanzieri, Tatiana M.
• Format: Article
• Language: English
• Subjects: Adult; Antibodies, Viral - blood; Child, Preschool; CMV; Colombia; Colombia - epidemiology; Confidence intervals; congenital infection; Cytomegalovirus; Cytomegalovirus - genetics; Cytomegalovirus - immunology; Cytomegalovirus Infections - congenital; Cytomegalovirus Infections - epidemiology; Cytomegalovirus Infections - immunology; Cytomegalovirus Infections - urine; DNA polymerase; DNA, Viral - urine; DNA-directed DNA polymerase; Epidemiology; Female; Gestation; Gestational Age; Humans; IgG antibody; Immunoglobulin G; Immunoglobulin G - blood; Infant; Infants; Infections; Mothers; newborns; Polymerase chain reaction; Postnatal infection; Pregnancy; Pregnancy Complications, Infectious - epidemiology; Pregnancy Complications, Infectious - immunology; Pregnancy Complications, Infectious - virology; prevalence; Saliva - virology; Seroepidemiologic Studies; Serology; seroprevalence; Virology
• ISSN: 0146-6615; 1096-9071
• DOI: 10.1002/jmv.26815

We assessed maternal and infant cytomegalovirus (CMV) infection in Colombia. Maternal serum was tested for CMV immunoglobulin G antibodies at a median of 10 (interquartile range: 8–12) weeks gestation (n = 1501). CMV DNA polymerase chain reaction was performed on infant urine to diagnose congenital (≤21 days of life) and postnatal (>21 days) infection. Maternal CMV seroprevalence was 98.1% (95% confidence interval [CI]: 97.5%–98.8%). Congenital CMV prevalence was 8.4 (95% CI: 3.9%–18.3%; 6/711) per 1000 live births. Among 472 infants without confirmed congenital CMV infection subsequently tested at age 6 months, 258 (54.7%, 95% CI: 50.2%–59.1%) had postnatal infection. Highlights In this multi‐city study in Colombia, maternal CMV seroprevalence was 98.1%, the prevalence of congenital CMV infection was 8.4 per 1000 live births, and 54.7% of infants had postnatal infection by 6 months of age.