Recent advances in design and applications of biomimetic self-assembled peptide hydrogels for hard tissue regeneration

The development of natural biomaterials applied for hard tissue repair and regeneration is of great importance, especially in societies with a large elderly population. Self-assembled peptide hydrogels are a new generation of biomaterials that provide excellent biocompatibility, tunable mechanical s...

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Bibliographic Details
Published in:Bio-design and manufacturing 2021-12, Vol.4 (4), p.735-756
Main Authors: Najafi, Haniyeh, Jafari, Mahboobeh, Farahavar, Ghazal, Abolmaali, Samira Sadat, Azarpira, Negar, Borandeh, Sedigheh, Ravanfar, Raheleh
Format: Article
Language:English
Subjects:
Amino acids
Biocompatibility
Biomaterials
Biomedical Engineering and Bioengineering
Biomedical materials
Bone growth
Bones
Cell culture
Collagen
Crystals
Dental enamel
Design
Electrolytes
Engineering
Extracellular matrix
Hydrogels
Hydroxyapatite
Immunogenicity
Mechanical Engineering
Nanostructured materials
Peptides
Phase transitions
Physiology
Polypeptides
Regeneration
Review
Tissue engineering
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Summary:The development of natural biomaterials applied for hard tissue repair and regeneration is of great importance, especially in societies with a large elderly population. Self-assembled peptide hydrogels are a new generation of biomaterials that provide excellent biocompatibility, tunable mechanical stability, injectability, trigger capability, lack of immunogenic reactions, and the ability to load cells and active pharmaceutical agents for tissue regeneration. Peptide-based hydrogels are ideal templates for the deposition of hydroxyapatite crystals, which can mimic the extracellular matrix. Thus, peptide-based hydrogels enhance hard tissue repair and regeneration compared to conventional methods. This review presents three major self-assembled peptide hydrogels with potential application for bone and dental tissue regeneration, including ionic self-complementary peptides, amphiphilic (surfactant-like) peptides, and triple-helix (collagen-like) peptides. Special attention is given to the main bioactive peptides, the role and importance of self-assembled peptide hydrogels, and a brief overview on molecular simulation of self-assembled peptide hydrogels applied for bone and dental tissue engineering and regeneration. Graphic abstract
ISSN:2096-5524
2522-8552
DOI:10.1007/s42242-021-00149-0