Liquoid-induced disseminated intravascular coagulation in the blue fox [platelets, hematocrit, DIC]

The present experiments were performed to study the effects of a single high intravenous dose of Liquoid (10 mg/kg body weight) upon platelets, coagulation activities and hematocrit in blue foxes, and their correlation with the survival time. Both “short-living” (< 9 h) and “long-living” (24 h or...

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Bibliographic Details
Published in:Acta veterinaria scandinavica 1982-01, Vol.23 (4), p.570-580
Main Authors: Lium, B, Dale, J, Aasen, A O
Format: Article
Language:English
Subjects:
Animals
Benzenesulfonates - adverse effects
Disseminated Intravascular Coagulation - chemically induced
Disseminated Intravascular Coagulation - veterinary
Female
Foxes
Male
Polyanetholesulfonate - adverse effects
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Summary:The present experiments were performed to study the effects of a single high intravenous dose of Liquoid (10 mg/kg body weight) upon platelets, coagulation activities and hematocrit in blue foxes, and their correlation with the survival time. Both “short-living” (< 9 h) and “long-living” (24 h or more) blue foxes showed a marked consumption of coagulation factors, initial fall in fibrinogen, positive ethanol gel test and a gradual decrease in platelet counts. In addition “short-living” animals developed a marked rise in hematocrit, reflecting a considerable increase in vascular permeability. We conclude that activation of plasma proteases has as one of its effects increased permeability in microvasculatory vessels and that this may play a central role for the course and outcome of Liquoid-induced disseminated intravascular coagulation.
ISSN:0044-605X
1751-0147
1751-0147
DOI:10.1186/BF03546776