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Expanding spectrum of “spitzoid” lesions: a small series of 4 cases with MAP2K1 mutations
The molecular background of a significant proportion of spitzoid neoplasms is still unknown. Recently, activating mutations in MAP2K1 have been described in a few spitzoid lesions, but not in benign Spitz nevi. We report four cases of melanocytic tumors with spitzoid features in which a MAP2K1 mutat...
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Published in: | Virchows Archiv : an international journal of pathology 2021-07, Vol.479 (1), p.195-202 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The molecular background of a significant proportion of spitzoid neoplasms is still unknown. Recently, activating mutations in
MAP2K1
have been described in a few spitzoid lesions, but not in benign Spitz nevi. We report four cases of melanocytic tumors with spitzoid features in which a
MAP2K1
mutation was detected. The lesions did not show a single distinct phenotype and ranged from benign to malignant. Two cases resembled desmoplastic Spitz nevi. Based on the combination of morphological, immunohistochemical, and molecular findings, one case was classified as benign, one as probably benign, possibly intermediate low-grade (MELTUMP—melanocytic tumor of unknown malignant potential), one case was classified as intermediate (MELTUMP), and one case was considered a superficial spreading melanoma with spitzoid features. Based on this, we conclude that
MAP2K1
mutations can indicate a spitzoid genetic signature and can be found in both benign and malignant spitzoid neoplasms. |
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ISSN: | 0945-6317 1432-2307 |
DOI: | 10.1007/s00428-020-02940-3 |