Preclinical In Vivo-Models to Investigate HIPEC; Current Methodologies and Challenges

Hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment modality for patients with peritoneal metastasis (PM) of various origins which aims for cure in combination with cytoreductive surgery (CRS). Efficacy of CRS-HIPEC depends on patient selection, tumor type, delivery technique, and treat...

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Bibliographic Details
Published in:Cancers 2021-07, Vol.13 (14), p.3430
Main Authors: Helderman, Roxan F. C. P. A., Löke, Daan R., Tanis, Pieter J., Tuynman, Jurriaan B., Ceelen, Wim, de Hingh, Ignace H., van der Speeten, Kurt, Franken, Nicolaas A. P., Oei, Arlene L., Kok, H. Petra, Crezee, Johannes
Format: Article
Language:English
Subjects:
Cancer therapies
Cell culture
Chemotherapy
Clinical trials
Colorectal cancer
Dosage
Drug dosages
Gastric cancer
Metastases
Ovarian cancer
Patients
Peritoneal diseases
Peritoneum
Physiology
Review
Surgery
Temperature
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Summary:Hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment modality for patients with peritoneal metastasis (PM) of various origins which aims for cure in combination with cytoreductive surgery (CRS). Efficacy of CRS-HIPEC depends on patient selection, tumor type, delivery technique, and treatment parameters such as temperature, carrier solution, type of drug, dosage, volume, and treatment duration. Preclinical research offers a powerful tool to investigate the impact of these parameters and to assist in designing potentially more effective treatment protocols and clinical trials. The different methodologies for peritoneal disease and HIPEC are variable. This study aims to review the objectives, methods, and clinical relevance of in vivo preclinical HIPEC studies found in the literature. In this review, recommendations are provided and possible pitfalls are discussed on the choice of type of animal and tumor model per stratified parameters and study goal. The guidelines presented in this paper can improve the clinical relevance and impact of future in vivo HIPEC experiments.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13143430