Gut and Endometrial Microbiome Dysbiosis: A New Emergent Risk Factor for Endometrial Cancer

Endometrial cancer is one of the most common gynaecological malignancies worldwide. Histologically, two types of endometrial cancer with morphological and molecular differences and also therapeutic implications have been identified. Type I endometrial cancer has an endometrioid morphology and is est...

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Bibliographic Details
Published in:Journal of personalized medicine 2021-07, Vol.11 (7), p.659
Main Authors: Boutriq, Soukaina, González-González, Alicia, Plaza-Andrades, Isaac, Laborda-Illanes, Aurora, Sánchez-Alcoholado, Lidia, Peralta-Linero, Jesús, Domínguez-Recio, María Emilia, Bermejo-Pérez, María José, Lavado-Valenzuela, Rocío, Alba, Emilio, Queipo-Ortuño, María Isabel
Format: Article
Language:English
Subjects:
Cancer
Colorectal cancer
Cyclin-dependent kinases
Dysbacteriosis
Endometrial cancer
Endometrium
Estrogens
Genes
Hormone replacement therapy
Hyperplasia
Infections
Menopause
Microbiomes
Microbiota
Mutation
Obesity
Ovaries
Precision medicine
Review
Risk factors
Tumors
Uterus
Vagina
Womens health
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Summary:Endometrial cancer is one of the most common gynaecological malignancies worldwide. Histologically, two types of endometrial cancer with morphological and molecular differences and also therapeutic implications have been identified. Type I endometrial cancer has an endometrioid morphology and is estrogen-dependent, while Type II appears with non-endometrioid differentiation and follows an estrogen-unrelated pathway. Understanding the molecular biology and genetics of endometrial cancer is crucial for its prognosis and the development of novel therapies for its treatment. However, until now, scant attention has been paid to environmental components like the microbiome. Recently, due to emerging evidence that the uterus is not a sterile cavity, some studies have begun to investigate the composition of the endometrial microbiome and its role in endometrial cancer. In this review, we summarize the current state of this line of investigation, focusing on the relationship between gut and endometrial microbiome and inflammation, estrogen metabolism, and different endometrial cancer therapies.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm11070659