Personalized Therapy and Liquid Biopsy—A Focus on Colorectal Cancer

(1) Background: Resistance mechanisms represent a barrier to anti-cancer therapies. Liquid biopsies would allow obtaining additional information in order to develop targeted therapies to thwart the resistance phenomena but also to follow in time real response to treatment and be able to adapt it the...

Full description

Saved in:
Bibliographic Details
Published in:Journal of personalized medicine 2021-07, Vol.11 (7), p.630
Main Authors: Christou, Niki, Veyrune, Léa, Popeskou, Sotirios Georgios, Mathonnet, Muriel
Format: Article
Language:English
Subjects:
Antigens
Biopsy
Cancer
Cancer therapies
Cell adhesion & migration
Colorectal cancer
Colorectal carcinoma
Genotype & phenotype
Metastasis
Methods
Mutation
Precision medicine
Review
Stem cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:(1) Background: Resistance mechanisms represent a barrier to anti-cancer therapies. Liquid biopsies would allow obtaining additional information in order to develop targeted therapies to thwart the resistance phenomena but also to follow in time real response to treatment and be able to adapt it the most quickly possible way in case of resistance. (2) Methods: herein we summarize the different liquid biopsies which are currently under research; we then review the literature and focalize on one of their potential roles: the theranostic one and especially in the cases of colorectal cancers. (3) Results: few studies targeting liquid biopsy as a potential tool to adapt cancer treatments are present in the literature and encompass few patients. (4) Conclusions: further research is needed to prove the efficiency of LB. Indeed, it seems a promising tool to guide treatment by targeting actionable mutations with detection of resistant mutations.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm11070630