Methotrexate-Loaded Gelatin and Polyvinyl Alcohol (Gel/PVA) Hydrogel as a pH-Sensitive Matrix

The aim was to formulate and evaluate Gel/PVA hydrogels as a pH-sensitive matrix to deliver methotrexate (MTX) to colon. The primed Gel/PVA hydrogels were subjected to evaluation for swelling behavior, diffusion coefficient, sol-gel characteristic and porosity using an acidic (pH 1.2) and phosphate...

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Bibliographic Details
Published in:Polymers 2021-07, Vol.13 (14), p.2300
Main Authors: Akhlaq, Muhammad, Azad, Abul Kalam, Ullah, Inam, Nawaz, Asif, Safdar, Muhammad, Bhattacharya, Tanima, Uddin, A. B. M. Helal, Abbas, Syed Atif, Mathews, Allan, Kundu, Sukalyan Kumar, Miret, Mireia Mallandrich, Murthy, H. C. Ananda, Nagaswarupa, H. P.
Format: Article
Language:English
Subjects:
Cancer therapies
Chemical compatibility
Chemotherapy
Colon
Colorectal cancer
Crosslinking
Diffusion coefficient
Drug delivery systems
Drug dosages
Equilibrium
Fourier transforms
Gelatin
Gravimetric analysis
Hydrogels
Infrared analysis
Kinetic equations
Leukemia
Mechanical properties
Methotrexate
Pharmaceuticals
Polymers
Polyvinyl alcohol
Potassium
Sol-gel processes
Solvents
Thermal analysis
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Summary:The aim was to formulate and evaluate Gel/PVA hydrogels as a pH-sensitive matrix to deliver methotrexate (MTX) to colon. The primed Gel/PVA hydrogels were subjected to evaluation for swelling behavior, diffusion coefficient, sol-gel characteristic and porosity using an acidic (pH 1.2) and phosphate buffer (PBS) (pH 6.8 & pH 7.4) media. Fourier transform infrared spectroscopy (FTIR) and thermal gravimetric analysis (TGA) were performed to evaluate the chemical compatibility of the Gel/PVA hydrogel. The shape alteration and release of Gel/PVA hydrogel was conducted at pH 1.2, pH 6.8 and pH 7.4. The drug release kinetic mechanism was determined using various kinetic equations. The physicochemical evaluation tests and drug release profile results were found to be significant (p < 0.01). However, it was dependent on the polymers’ concentration, the pH of the release media and the amount of the cross-linking agent. Hydrogels containing the maximum amount of gel showed a dynamic equilibrium of 10.09 ± 0.18 and drug release of 93.75 ± 0.13% at pH 1.2. The kinetic models showed the release of MTX from the Gel/PVA hydrogel was non-Fickian. The results confirmed that the newly formed Gel/PVA hydrogels are potential drug delivery systems for a controlled delivery of MTX to the colon.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym13142300