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The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure–Function Relationships in Mammalian SLC6 Transporters
To the SLC6 family belong 20 human transporters that utilize the sodium electrochemical gradient to move biogenic amines, osmolytes, amino acids and related compounds into cells. They are classified into two functional groups, the Neurotransmitter transporters (NTT) and Nutrient amino acid transport...
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| Published in: | Neurochemical research 2022-01, Vol.47 (1), p.111-126 |
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| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c474t-7ecd3b1dc94289d373d57f12838681e52b89b8b5ceccf2a30bc72edb360bb6003 |
| container_end_page | 126 |
| container_issue | 1 |
| container_start_page | 111 |
| container_title | Neurochemical research |
| container_volume | 47 |
| creator | Castagna, Michela Cinquetti, Raffaella Verri, Tiziano Vacca, Francesca Giovanola, Matteo Barca, Amilcare Romanazzi, Tiziana Roseti, Cristina Galli, Alessandra Bossi, Elena |
| description | To the SLC6 family belong 20 human transporters that utilize the sodium electrochemical gradient to move biogenic amines, osmolytes, amino acids and related compounds into cells. They are classified into two functional groups, the Neurotransmitter transporters (NTT) and Nutrient amino acid transporters (NAT). Here we summarize how since their first cloning in 1998, the insect (
Lepidopteran
)
Orthologs
of the SLC6 family transporters have represented very important tools for investigating functional–structural relationships, mechanism of transport, ion and pH dependence and substate interaction of the mammalian (and human) counterparts. |
| doi_str_mv | 10.1007/s11064-021-03410-1 |
| format | article |
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Lepidopteran
)
Orthologs
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Lepidopteran
)
Orthologs
of the SLC6 family transporters have represented very important tools for investigating functional–structural relationships, mechanism of transport, ion and pH dependence and substate interaction of the mammalian (and human) counterparts.</description><subject>Amines</subject><subject>Amino Acid Transport Systems - metabolism</subject><subject>Amino acids</subject><subject>Animals</subject><subject>Binding sites</subject><subject>Biochemistry</subject><subject>Biogenic amines</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain research</subject><subject>Carrier Proteins - metabolism</subject><subject>Cell Biology</subject><subject>Chloride</subject><subject>Cloning</subject><subject>Dopamine</subject><subject>Electrochemistry</subject><subject>Functional groups</subject><subject>Genes</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Insect Proteins - chemistry</subject><subject>Insect Proteins - genetics</subject><subject>Insect Proteins - metabolism</subject><subject>Insects</subject><subject>Laboratories</subject><subject>Mammals</subject><subject>Mammals - metabolism</subject><subject>Membrane Proteins - metabolism</subject><subject>Neurochemistry</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Neurotransmitters</subject><subject>Original Paper</subject><subject>Physiology</subject><subject>Structure-Activity Relationship</subject><subject>Structure-function relationships</subject><issn>0364-3190</issn><issn>1573-6903</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kc2KFDEUhYMoTjv6Ai4k4GY2pfcmVZUqF0LTOCq2DDg965BKpbszVCVlkhJcCL6Db-iTmLbH8WfhKhfud87J5RDyGOEZAojnERHqsgCGBfASocA7ZIGV4EXdAr9LFsDzmmMLJ-RBjNcAWcbwPjnhJYeSC7YgXzZ7Q9dmsr2fkgnK0XfL5Qapcj1d5Wn1Bl_Qi5D2fvC7SJOnV643IaYDcJnCrNMczPev385np5P1jn4wgzoMcW-nSK2j79U4qsFm68v1qqabHBInH3JafEjubdUQzaOb95Rcnb_KmcX64vXb1XJd6FKUqRBG97zDXrcla9qeC95XYous4U3doKlY17Rd01XaaL1likOnBTN9x2vouhqAn5KXR99p7kbTa-NSUIOcgh1V-Cy9svLvjbN7ufOfZMMRSiyzwdmNQfAfZxOTHG3UZhiUM36OklVVxSto8JD19B_02s_B5fMkqxk0XAioMsWOlA4-xmC2t59BkId25bFdmQuTP9uVmEVP_jzjVvKrzgzwIxDzyu1M-J39H9sftOixkw</recordid><startdate>20220101</startdate><enddate>20220101</enddate><creator>Castagna, Michela</creator><creator>Cinquetti, Raffaella</creator><creator>Verri, Tiziano</creator><creator>Vacca, Francesca</creator><creator>Giovanola, Matteo</creator><creator>Barca, Amilcare</creator><creator>Romanazzi, Tiziana</creator><creator>Roseti, Cristina</creator><creator>Galli, Alessandra</creator><creator>Bossi, Elena</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9549-2153</orcidid></search><sort><creationdate>20220101</creationdate><title>The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure–Function Relationships in Mammalian SLC6 Transporters</title><author>Castagna, Michela ; Cinquetti, Raffaella ; Verri, Tiziano ; Vacca, Francesca ; Giovanola, Matteo ; Barca, Amilcare ; Romanazzi, Tiziana ; Roseti, Cristina ; Galli, Alessandra ; Bossi, Elena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-7ecd3b1dc94289d373d57f12838681e52b89b8b5ceccf2a30bc72edb360bb6003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Amines</topic><topic>Amino Acid Transport Systems - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neurochemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Castagna, Michela</au><au>Cinquetti, Raffaella</au><au>Verri, Tiziano</au><au>Vacca, Francesca</au><au>Giovanola, Matteo</au><au>Barca, Amilcare</au><au>Romanazzi, Tiziana</au><au>Roseti, Cristina</au><au>Galli, Alessandra</au><au>Bossi, Elena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure–Function Relationships in Mammalian SLC6 Transporters</atitle><jtitle>Neurochemical research</jtitle><stitle>Neurochem Res</stitle><addtitle>Neurochem Res</addtitle><date>2022-01-01</date><risdate>2022</risdate><volume>47</volume><issue>1</issue><spage>111</spage><epage>126</epage><pages>111-126</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><abstract>To the SLC6 family belong 20 human transporters that utilize the sodium electrochemical gradient to move biogenic amines, osmolytes, amino acids and related compounds into cells. They are classified into two functional groups, the Neurotransmitter transporters (NTT) and Nutrient amino acid transporters (NAT). Here we summarize how since their first cloning in 1998, the insect (
Lepidopteran
)
Orthologs
of the SLC6 family transporters have represented very important tools for investigating functional–structural relationships, mechanism of transport, ion and pH dependence and substate interaction of the mammalian (and human) counterparts.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34304372</pmid><doi>10.1007/s11064-021-03410-1</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-9549-2153</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0364-3190 |
| ispartof | Neurochemical research, 2022-01, Vol.47 (1), p.111-126 |
| issn | 0364-3190 1573-6903 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8310414 |
| source | Springer Nature |
| subjects | Amines Amino Acid Transport Systems - metabolism Amino acids Animals Binding sites Biochemistry Biogenic amines Biomedical and Life Sciences Biomedicine Brain research Carrier Proteins - metabolism Cell Biology Chloride Cloning Dopamine Electrochemistry Functional groups Genes Homeostasis Humans Insect Proteins - chemistry Insect Proteins - genetics Insect Proteins - metabolism Insects Laboratories Mammals Mammals - metabolism Membrane Proteins - metabolism Neurochemistry Neurology Neurosciences Neurotransmitters Original Paper Physiology Structure-Activity Relationship Structure-function relationships |
| title | The Lepidopteran KAAT1 and CAATCH1: Orthologs to Understand Structure–Function Relationships in Mammalian SLC6 Transporters |
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