Association of the CYP1A1 rs4646903 polymorphism with susceptibility and severity of coronary artery disease

Given the significant physical, mental, and economic problems of coronary artery disease (CAD), it is important for communities to help reduce these costs. The Cytochrome P450 Family 1 Subfamily A Member 1) CYP1A1 (enzyme is known to cause coronary artery disease through various mechanisms. Therefor...

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Published in:Molecular biology research communications 2021-06, Vol.10 (2), p.22-61
Main Authors: Eskandari, Mahsa, Awsat Mellati, Ali, Mahmoodi, Khalil, Kamali, Koorosh, Soltanpour, Mohammad Soleiman
Format: Article
Language:English
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Summary:Given the significant physical, mental, and economic problems of coronary artery disease (CAD), it is important for communities to help reduce these costs. The Cytochrome P450 Family 1 Subfamily A Member 1) CYP1A1 (enzyme is known to cause coronary artery disease through various mechanisms. Therefore, it is important to investigate the polymorphisms that affect the activity of this enzyme. After collecting samples from 191 patients with angiographically verified CAD and 191 healthy individuals, genotyping for CYP1A1 rs4646903 polymorphism was carried out. Lipid profile was assessed by conventional colorimetric method. The results showed that the frequency of heterozygous and homozygous mutant genotypes of rs4646903 polymorphism was 36.6% and 5.2% in patients and 20.9% and 2.1% in controls, respectively. The heterozygous genotype (OR=2.24; 95% CI=1.30-3.84, P=0.003), homozygous mutant genotype (OR=3.97; 95% CI=1.05-14.98, P=0.042) and mutant C allele (OR=2.15; 95% CI=1.46-3.15, P0.05). In conclusion, the rs4646903 polymorphism contributed to the susceptibleness of people to CAD.
ISSN:2322-181X
2345-2005
DOI:10.22099/mbrc.2021.39141.1574