Magnitude and variability of structural brain abnormalities in neuropsychiatric disease: protocol for a network meta-analysis of MRI studies

IntroductionStructural MRI is the most frequently used method to investigate brain volume alterations in neuropsychiatric disease. Previous meta-analyses have typically focused on a single diagnosis, thereby precluding transdiagnostic comparisons.Methods and analysisWe will include all structural MR...

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Published in:BMJ mental health 2021-08, Vol.24 (3), p.111-114
Main Authors: McCutcheon, Robert, Pillinger, Toby, Welby, George, Vano, Luke, Cummings, Connor, Guo, Xin, Heron, Toni Ann, Efthimiou, Orestis, Cipriani, Andrea, Howes, Oliver
Format: Article
Language:English
Subjects:
Age
Anxiety disorders
Autism
Bipolar disorder
Brain
Drug use
Ethnicity
Gender
Magnetic resonance imaging
Mental depression
Mental disorders
Meta-analysis
Pathophysiology
Personality disorders
Post traumatic stress disorder
Protocol
Psychosis
Schizoaffective disorder
Schizophrenia
Schizotypal personality disorder
Systematic review
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Summary:IntroductionStructural MRI is the most frequently used method to investigate brain volume alterations in neuropsychiatric disease. Previous meta-analyses have typically focused on a single diagnosis, thereby precluding transdiagnostic comparisons.Methods and analysisWe will include all structural MRI studies of adults that report brain volumes for participants from at least two of the following diagnostic groups: healthy controls, schizophrenia, schizoaffective disorder, delusional disorder, psychotic depression, clinical high risk for psychosis, schizotypal personality disorder, psychosis unspecified, bipolar disorder, autism spectrum disorder, major depressive disorder, attention deficit hyperactivity disorder, obsessive compulsive disorder, post-traumatic stress disorder, emotionally unstable personality disorder, 22q11 deletion syndrome, generalised anxiety disorder, social anxiety disorder, panic disorder, mixed anxiety and depression. Network meta-analysis will be used to synthesise eligible studies. The primary analysis will examine standardised mean difference in average volume, a secondary analysis will examine differences in variability of volumes.DiscussionThis network meta-analysis will provide a transdiagnostic integration of structural neuroimaging studies, providing researchers with a valuable summary of a large literature.PROSPERO registration numberCRD42020221143.
ISSN:1362-0347
1468-960X
2755-9734
DOI:10.1136/ebmental-2020-300229