Synthetic Carbohydrate Chemistry and Translational Medicine

The importance of post-translational glycosylation in protein structure and function has gained significant clinical relevance recently. The latest developments in glycobiology, glycochemistry, and glycoproteomics have made the field more manageable and relevant to disease progression and immune-res...

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Bibliographic Details
Published in:Journal of organic chemistry 2020-12, Vol.85 (24), p.15780-15800
Main Authors: Shivatare, Sachin S, Wong, Chi-Huey
Format: Article
Language:English
Subjects:
Carbohydrates
Glycosylation
Polysaccharides
Proteins
Translational Research, Biomedical
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Summary:The importance of post-translational glycosylation in protein structure and function has gained significant clinical relevance recently. The latest developments in glycobiology, glycochemistry, and glycoproteomics have made the field more manageable and relevant to disease progression and immune-response signaling. Here, we summarize the current progress in glycoscience, including the new methodologies that have led to the introduction of programmable and automatic as well as large-scale enzymatic synthesis, and the development of glycan array, glycosylation probes, and inhibitors of carbohydrate-associated enzymes or receptors. These novel methodologies and tools have facilitated our understanding of the significance of glycosylation and development of carbohydrate-derived medicines that bring the field to the next level of scientific and medical significance.
ISSN:0022-3263
1520-6904
1520-6904
DOI:10.1021/acs.joc.0c01834