The input of GATA-3 in the identification of parathyroid carcinoma diagnosis: Case report with review of literature

and Importance: Parathyroid carcinoma is an exceptional cancer, with significant morbidity and mortality, associated with parathyroid hormone (PTH) mediated hypercalcemia. We report a case of parathyroid carcinoma with a difficult histological diagnosis. This case illustrates the usefulness of the i...

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Bibliographic Details
Published in:Annals of medicine and surgery 2021-08, Vol.68, Article 102571
Main Authors: Lajmi, Zainab, Bdioui, Ahlem, Bchir, Ahlem, Oussama belkacem, Ben Ammou, Emene, Missaoui, Nabiha, Hmissa, Sihem
Format: Article
Language:English
Subjects:
Carcinoma
Case Report
Diagnosis
GATA-3
Immunohistochemistry
Parathyroid
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Summary:and Importance: Parathyroid carcinoma is an exceptional cancer, with significant morbidity and mortality, associated with parathyroid hormone (PTH) mediated hypercalcemia. We report a case of parathyroid carcinoma with a difficult histological diagnosis. This case illustrates the usefulness of the immunohistochemical marker “GATA-3” in parathyroid differentiation especially in tumours. The diagnosis of parathyroid carcinoma is challenging without the knowledge of the clinical information, laboratory finding, and radiographic imaging studies. The immunohistochemistry is useful tool in these cases to identify the parathyroid origin of neoplasia. GATA-3 is a transcription factor that is involved in the embryonic development of the parathyroid glands and in adult parathyroid cell proliferation. It is concluded that GATA-3 is a very sensitive and relatively specific immunohistochemical marker for parathyroid differentiation that can assist in the differential diagnosis of parathyroid tumours. •Input of GATA-3 in the identification of parathyroid carcinoma.
ISSN:2049-0801
2049-0801
DOI:10.1016/j.amsu.2021.102571