A Scalable Random Access Micro-traps Array for Formation, Selective Retrieval and Capturing of Individual Droplets

Formation, selective retrieval and capturing of individual droplets are key operational capabilities needed for a broad range of droplet microfluidic applications. The membrane displacement trap (MDT) element gives a robust method for uniform discretization and controllable manipulation of aqueous d...

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Bibliographic Details
Main Authors: Babahosseini, H., Padmanabhan, S., Misteli, T., DeVoe, D. L.
Format: Conference Proceeding
Language:English
Subjects:
Biomembranes
Cancer
Liquids
Microfluidics
Multiplexing
Oils
Valves
Online Access:Get full text
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Summary:Formation, selective retrieval and capturing of individual droplets are key operational capabilities needed for a broad range of droplet microfluidic applications. The membrane displacement trap (MDT) element gives a robust method for uniform discretization and controllable manipulation of aqueous droplets using an enclosed micro-well covered by an elastomer membrane. This capability can be scaled up by combining the modular elements with a system design that requires a minimal number of signal inputs. Incorporation of MDT elements with a pneumatically-controllable multiplexer system can lead to a scalable random access MDT array platform for liquid discretization and selective manipulation. Herein, we report the design and development of a programmable droplet microfluidic platform for liquid sampling and selectively handling up to 32 individual droplets using 10 pneumatic signal inputs. The multiplexer system can logarithmically scale up capacity of the MDT array platform, making it possible to manipulate hundreds droplets.
ISSN:2375-7477
1558-4615
2694-0604
DOI:10.1109/EMBC.2019.8857768