Quercetin as a nephroprotector after warm ischemia: histomorphometric evaluation in a rodent model

ABSTRACT Purpose: To quantitatively evaluate the possible long-term protective effects of quercetin during renal warm ischemia. Materials and Methods: Male rats were allocated into 4 groups: sham (S), sham quercetin (SQ), ischemia (I), and ischemia quercetin (IQ). Groups SQ and IQ received quercetin...

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Bibliographic Details
Published in:International Brazilian Journal of Urology 2021-07, Vol.47 (4), p.796-802
Main Authors: Gonçalves, Gabriela F. Buys, Silva, Maria Eduarda M., Sampaio, Francisco J. B., Pereira-Sampaio, Marco A., Souza, Diogo Benchimol de
Format: Article
Language:English
Subjects:
Nephrectomy
Original
Quercetin
Warm Ischemia
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Summary:ABSTRACT Purpose: To quantitatively evaluate the possible long-term protective effects of quercetin during renal warm ischemia. Materials and Methods: Male rats were allocated into 4 groups: sham (S), sham quercetin (SQ), ischemia (I), and ischemia quercetin (IQ). Groups SQ and IQ received quercetin (50mg/kg) before and after surgery. Groups I and IQ had their left renal vessels clamped for 60 minutes. All animals were euthanized four weeks after the procedure, and serum urea and creatinine levels were measured. Renal weight and volume, cortex-non-cortex area ratio (C-NC), cortical volume (CV), glomerular volumetric density (Vv[glom]), volume-weighted glomerular volume (VWGV) and number of glomeruli per kidney (N[glom]) were evaluated by stereological methods. Results were considered statistically significant when p
ISSN:1677-5538
1677-6119
DOI:10.1590/s1677-5538.ibju.2020.0358