Prophylactic Probiotic Supplementation for Preterm Neonates—A Systematic Review and Meta-Analysis of Nonrandomized Studies

Systematic review and meta-analyses of randomized controlled trials (RCTs) show that probiotics reduce the risk of necrotizing enterocolitis (NEC ≥ Stage II), late onset sepsis (LOS), all-cause mortality, and feeding intolerance in preterm neonates. Data from observational studies is important to co...

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Bibliographic Details
Published in:Advances in nutrition (Bethesda, Md.) Md.), 2021-07, Vol.12 (4), p.1411-1423
Main Authors: Deshmukh, Mangesh, Patole, Sanjay
Format: Article
Language:English
Subjects:
enterocolitis
Enterocolitis, Necrotizing - prevention & control
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases
low birth weight
meta-analysis
mortality
necrotizing enterocolitis
neonates
nutrition
outcomes
pregnancy
preterm infant
Probiotics
Review
risk reduction
Sepsis - prevention & control
systematic review
very low birth weight
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Summary:Systematic review and meta-analyses of randomized controlled trials (RCTs) show that probiotics reduce the risk of necrotizing enterocolitis (NEC ≥ Stage II), late onset sepsis (LOS), all-cause mortality, and feeding intolerance in preterm neonates. Data from observational studies is important to confirm probiotic effects in clinical practice. We aimed to compare outcomes before and after implementing routine probiotic supplementation (RPS) in preterm neonates (
ISSN:2161-8313
2156-5376
2156-5376
DOI:10.1093/advances/nmaa164