Comparison of Long- and Short-term Outcomes in 845 Open and Minimally Invasive Gastrectomies for Gastric Cancer in the United States

• Published in: Annals of surgical oncology 2021-07, Vol.28 (7), p.3532-3544
• Main Authors: Nakauchi, Masaya, Vos, Elvira, Janjigian, Yelena Y., Ku, Geoffrey Y., Schattner, Mark A., Nishimura, Makoto, Gonen, Mithat, Coit, Daniel G., Strong, Vivian E.
• Format: Article
• Language: English
• Subjects: Adenocarcinoma; Gastrectomy; Gastric cancer; Gastrointestinal Oncology; Gastrointestinal surgery; Humans; Laparoscopy; Length of Stay; Medicine; Medicine & Public Health; Minimally Invasive Surgical Procedures; Oncology; Retrospective Studies; Robotic surgery; Robotic Surgical Procedures; Robotics; Stomach Neoplasms - surgery; Surgery; Surgical Oncology; Survival; Treatment Outcome; United States - epidemiology
• ISSN: 1068-9265; 1534-4681
• DOI: 10.1245/s10434-021-09798-y

Background Few Western studies have evaluated the long-term oncologic outcomes of minimally invasive surgery (MIS) approaches to gastrectomy for gastric cancer. This study aimed to compare the outcomes between minimally invasive and open gastrectomies and between laparoscopic and robotic gastrectomies at a high-volume cancer center in the United States. Methods The study analyzed data for all patients undergoing curative gastrectomy for gastric adenocarcinoma from January 2007 to June 2017. Postoperative complications and disease-specific survival (DSS) were compared between surgical approaches. Results The median follow-up period for the 845 patients in this study was 38.5 months. The stage-stratified 5-year DSS did not differ significantly between open surgery ( n  = 534) and MIS ( n = 311). The MIS approach resulted in significantly fewer complications, as confirmed by adjusted comparison (odds ratio [OR], 0.70; range, 0.49–1.00; p = 0.049). After adjustment, the two groups did not differ in terms of DSS (hazard ratio [HR], 0.83; range, 0.55–1.25; p = 0.362). The robotic operations ( n = 190) had fewer conversions to open procedure ( p = 0.010), a shorter operative time (212 vs 240 min; p < 0.001), more dissected nodes (27 vs 22; p < 0.001), fewer Clavien-Dindo grade ≥3 complications (5.8% vs 13.2%; p = 0.023), and a shorter postoperative stay (5 vs 6 days; p = 0.045) than the laparoscopic operations ( n = 121). The DSS rate did not differ between the laparoscopic and robotic groups. Conclusion The study findings demonstrated the long-term survival and oncologic equivalency of MIS gastrectomy and the open approach in a Western cohort, supporting the use of MIS at centers that have adequate experience with appropriately selected patients.