NREM Sleep EEG Characteristics Correlate to the Mild Cognitive Impairment in Patients with Parkinsonism

• Published in: BioMed research international 2021, Vol.2021, p.5561974-10
• Main Authors: Zhang, Cheng, Wei, Luhua, Zeng, Fengqingyang, Zhang, Tingwei, Sun, Yunchuang, Shen, Yane, Wang, Guangfa, Ma, Jing, Zhang, Jue
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Alzheimer's disease; Area Under Curve; Basal ganglia; Biomarkers; Brain diseases; Case-Control Studies; Central nervous system diseases; Cognition & reasoning; Cognition disorders; Cognitive ability; Cognitive Dysfunction - complications; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - physiopathology; Complications and side effects; Dementia; Diagnosis; EEG; Electroencephalography; Electromyography; Eye; Eye movements; Female; Humans; Impairment; Male; Middle Aged; Movement disorders; Movements; NREM sleep; Parkinson's disease; Parkinsonian Disorders - complications; Parkinsonian Disorders - diagnostic imaging; Parkinsonian Disorders - physiopathology; Parkinsonism; Patients; Polysomnography; REM sleep; Risk factors; ROC Curve; Sleep; Sleep and wakefulness; Sleep Stages - physiology; Spectra; Spectral analysis; Spectrum analysis; Stages; Time series; Wakefulness; Wakefulness - physiology
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2021/5561974

Early identification and diagnosis of mild cognitive impairment (MCI) in patients with parkinsonism (PDS) are critical. The aim of this study was to identify biomarkers of MCI in PDS using conventional electroencephalogram (EEG) power spectral analysis and detrended fluctuation analysis (DFA). In this retrospective study, patients with PDS who underwent an overnight polysomnography (PSG) study in our hospital from 2019 to 2020 were enrolled. Patients with PDS assessed by clinical examination and questionnaires were divided into two groups: the PDS with normal cognitive function (PDS-NC) group and the PDS with MCI (PDS-MCI) group. Sleep EEG signals were extracted and purified from the PSG and subjected to a conventional power spectral analysis, as well as detrended fluctuation analysis (DFA) during wakefulness, nonrapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep. Forty patients with PDS were enrolled, including 25 with PDS-NC and 15 with PDS-MCI. Results revealed that compared with PDS-NC patients, patients with PDS-MCI had a reduced fast ratio (alpha+beta/delta+theta) and increased DFA during NREM sleep. DFA during NREM was diagnostic of PDS-MCI, with an area under the receiver operating characteristic curve of 0.753 (95% CI: 0.592–0.914) (p