MR of brain radiation injury: experimental studies in cats

Two of six cats receiving small-field, single-dose, brain irradiation of 35 Gy with 6 MeV photons developed brain abnormalities in the irradiated area on MR images at 6 and 8 months, respectively, after treatment. The lesions were of high intensity on T2-weighted images and did not enhance after IV...

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Bibliographic Details
Published in:American journal of neuroradiology : AJNR 1987-05, Vol.8 (3), p.427-430
Main Authors: Hecht-Leavitt, C, Grossman, RI, Curran, WJ, Jr, McGrath, JT, Biery, DN, Joseph, PM, Nelson, DF
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain Injuries - pathology
Cats
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Spectroscopy
Medical sciences
Myelin Sheath - pathology
Necrosis
Nervous system
Radiation Injuries, Experimental - pathology
Radiodiagnosis. Nmr imagery. Nmr spectrometry
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Summary:Two of six cats receiving small-field, single-dose, brain irradiation of 35 Gy with 6 MeV photons developed brain abnormalities in the irradiated area on MR images at 6 and 8 months, respectively, after treatment. The lesions were of high intensity on T2-weighted images and did not enhance after IV administration of gadolinium-DTPA. An additional lesion in one of these cats displayed high signal on T2-weighted images and enhanced on T1-weighted images after IV gadolinium-DTPA. Pathologic correlation revealed that the nonenhancing T2-weighted lesions consisted of edema or demyelinated regions without inflammation while the gadolinium-enhanced lesion demonstrated necrosis with inflammatory infiltrate. Focal brain irradiation may produce noninflammatory demyelination and necrosis. These histologic entities may be potentially distinguished on MR with IV gadolinium-DTPA.
ISSN:0195-6108
1936-959X