Osmotic blood-brain barrier disruption: CT and radionuclide imaging

• Published in: American journal of neuroradiology : AJNR 1994-03, Vol.15 (3), p.581-590
• Main Authors: Roman-Goldstein, S, Clunie, DA, Stevens, J, Hogan, R, Monard, J, Ramsey, F, Neuwelt, EA
• Format: Article
• Language: English
• Subjects: 560160 > Radionuclide Effects, Kinetics, & Toxicology; Adolescent; Adult; Aged; Biological and medical sciences; BLOOD-BRAIN BARRIER; Blood-Brain Barrier - physiology; BODY; BRAIN; Brain Neoplasms - diagnostic imaging; Brain Neoplasms - physiopathology; CENTRAL NERVOUS SYSTEM; COMPARATIVE EVALUATIONS; Comparative Study; COMPUTERIZED TOMOGRAPHY; CONTRAST MEDIA; COUNTING TECHNIQUES; DIAGNOSTIC TECHNIQUES; EVALUATION; Female; Humans; Investigative techniques, diagnostic techniques (general aspects); IOPAMIDOL; Male; Medical sciences; Middle Aged; NERVOUS SYSTEM; Organotechnetium Compounds; ORGANS; Osmosis; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT; Radiodiagnosis. Nmr imagery. Nmr spectrometry; RADIOISOTOPE SCANNING; RADIOLOGY AND NUCLEAR MEDICINE; Radionuclide Imaging; Research Support, U.S. Gov't, Non-P.H.S; Research Support, U.S. Gov't, P.H.S; RESOLUTION; SPATIAL RESOLUTION; Sugar Acids; TOMOGRAPHY 550601 > Medicine-- Unsealed Radionuclides in Diagnostics; Tomography, X-Ray Computed; TOXICITY
• ISSN: 0195-6108; 1936-959X

To compare CT and radionuclide imaging of osmotic blood-brain barrier disruption. To develop a quantitative method for imaging osmotic blood-brain barrier disruption and to see if iopamidol could be safely given intravenously in conjunction with blood-brain barrier disruption. Forty-five blood-brain barrier disruption procedures were imaged with CT and radionuclide scans. The scans were evaluated with visual and quantitative scales. Patients were observed for adverse effects after blood-brain barrier disruption. There was a 4% rate of seizures in this study. There was good agreement between visual CT and radionuclide grading systems. Quantitative methods to grade disruption did not add useful information to visual interpretations. Nonionic iodine-based contrast medium has a lower incidence of seizures when injected intravenously in conjunction with osmotic blood-brain barrier disruption than ionic contrast material. Contrast-enhanced CT is the preferred method to image disruption because it has better spatial resolution than radionuclide techniques.