Rabies Infection: An Overview of Lyssavirus-Host Protein Interactions

Viruses are obligatory intracellular parasites that use cell proteins to take the control of the cell functions in order to accomplish their life cycle. Studying the viral-host interactions would increase our knowledge of the viral biology and mechanisms of pathogenesis. Studies on pathogenesis mech...

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Bibliographic Details
Published in:Iranian biomedical journal 2021-07, Vol.25 (4), p.226-242
Main Authors: Zandi, Fatemeh, Goshadrou, Fatemeh, Meyfour, Anna, Vaziri, Behrouz
Format: Article
Language:English
Subjects:
Animals
Exploitation
Host Microbial Interactions - physiology
Humans
Infections
Life cycles
Lyssavirus
Lyssavirus - metabolism
Parasites
Pathogenesis
Phagocytosis - physiology
Protein Binding - physiology
Protein interaction
Proteins
Rabies
Rabies - metabolism
Rabies - transmission
Rabies virus - metabolism
Review
Viruses
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Description
Summary:Viruses are obligatory intracellular parasites that use cell proteins to take the control of the cell functions in order to accomplish their life cycle. Studying the viral-host interactions would increase our knowledge of the viral biology and mechanisms of pathogenesis. Studies on pathogenesis mechanisms of lyssaviruses, which are the causative agents of rabies, have revealed some important host protein partners for viral proteins, especially for most studied species, i.e. Rabies virus. In this review article, the key physical lyssavirus-host protein interactions, their contributions to rabies infection, and their exploitation are discussed to improve the knowledge about rabies pathogenesis.
ISSN:1028-852X
2008-823X
DOI:10.52547/ibj.25.4.226