Positron emission tomographic studies of aging and Alzheimer disease

In this study the positron emission tomographic (PET)-18F-2-deoxy-2-fluoro-D-glucose (FDG) technique was used to study both normal aging and senile dementia. The results derived from 15 young normal subjects (mean age, 26 +/- 5 years) and 22 elderly normal subjects (mean age, 66 +/- 7 years) failed...

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Bibliographic Details
Published in:American journal of neuroradiology : AJNR 1983-05, Vol.4 (3), p.568-571
Main Authors: de Leon, MJ, Ferris, SH, George, AE, Christman, DR, Fowler, JS, Gentes, C, Reisberg, B, Gee, B, Emmerich, M, Yonekura, Y, Brodie, J, Kricheff, II, Wolf, AP
Format: Article
Language:English
Subjects:
Adult
Aged
Aging
Alzheimer Disease - blood
Alzheimer Disease - diagnostic imaging
Blood Glucose - metabolism
Dementia - blood
Dementia - diagnostic imaging
Deoxyglucose - analogs & derivatives
Fluorodeoxyglucose F18
Humans
Middle Aged
Research Support, U.S. Gov't, P.H.S
Tomography, Emission-Computed - methods
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Summary:In this study the positron emission tomographic (PET)-18F-2-deoxy-2-fluoro-D-glucose (FDG) technique was used to study both normal aging and senile dementia. The results derived from 15 young normal subjects (mean age, 26 +/- 5 years) and 22 elderly normal subjects (mean age, 66 +/- 7 years) failed to indicate significant metabolic changes associated with age. A group of 24 patients with senile dementia (mean age, 73 +/- 7 years) showed consistent diminutions in regional glucose use relative to the elderly normals. Across all brain regions the diminutions were 17%-24%. There were also significant correlations between the measures of glucose use and the measures of cognitive functioning. Discriminant function classification analysis results indicate that better than 80% classification accuracy can be achieved for individual PET measures. These data suggest a possible future diagnostic use of PET in senile dementia.
ISSN:0195-6108
1936-959X